Controllable Self-assembled Supramolecules Using Electrostatic Interaction

One of the most intriguing features in the hierarchical assembly of biomolecular subunits in nature is their mutual cooperation to carry out versatile tasks at the global level with remarkable precision1,2.The collective motion of complex protein machines as an example mediates essential functions for life such as replication3,synthesis4,degradation5,repair6,and transport7.Nucleic acid molecules are far less dynamic,binding specific proteins to form hierarchical structures.The simplest example of the nucleic acid-based structures is provided by a rod-shaped tobacco mosaic virus(TMV)which consists of genetic material surrounded by coat proteins8.Motivated by the complexity and hierarchical assembly of viruses,a great deal of effort has been devoted to design artificial viruses by wrapping genetic material with synthetic coat assembly9,10.However,such wrapping approaches make dynamic molecules insensitive to environmental changes.This limitation generally restricts hierarchical structuring for the amplification of the lower level motion of genetic materials.Double stranded DNA is conformationally dynamic and adopts a variety of secondary structures ranging from the canonical right-handed B-form to the left-handed Z conformation11,12.Based on this mechanistic insight,translating its individual motion into a higher level of coat assembly may provide an approach for creating DNA-based hierarchical nanomachines undergoing collective motion upon stimulation by external triggers.Here we report virus-like hierarchical assembly that undergoes repeated collective motion in helicity switching ofnative DNA and synthetic coat assembly triggered by p H change under physiological conditions.Additionally,the collective helicity inversion of the DNA-coat assembly is also followed by its translocation into intracellular compartments.In the second part,the main research is the aggregation induced emission phenomenon.Today’s society,science and technology developing very fast,the materials which people need is more and more demanding,more and more qualified.designed and developed of new function with special features materials has become one of the hot research.Organic fluorescent materials have become one of the most popular research topics because of their extensive source of raw materials,relatively simple processing methods and excellent photoelectric properties.The application of organic fluorescent materials is very extensive,including the use of synthetic fibers,biological probes,electroluminescence and other high-tech fields.with aggregation-induced emission of the compound is in the single molecule state,the fluorescence is weak or even no fluorescence,and In the aggregation state,the fluorescence is enhanced,which is the aggregation induced emission phenomenon.The properties of induced emission are related to the temperature,pressure,and its concentration,in addition to its own structure.In this reaserch,we designed a nanosheet with negatively charged surfaces,while the organic small molecules(dye molecules)with distyrylanthracene as nuclei were positively charged with quaternary ammonium salts,The role of the organic small molecules to the nanosheet and on the above aggregation,resulting in aggregation-induced emission phenomenon.There are three chapters in this paper.The chapter 1 and chapter 2 have published in the Nature Nanotechnol.2017.The chapter 1 and chapter 2 are focused on the Collective helicity switching of a DNA-coat assembly.The chapter 3 is the work which we are focused on now.In the chapter 1,we introduce how can we make self-assembly of coat molecules driven byDNA and collective helicity switching of DNA-coat assembly.Double stranded DNA is conformationally dynamic and adopts a variety of secondary structures ranging from the canonical right-handed B-form to the left-handed Z conformation.Based on this mechanistic insight,translating its individual motion into a higher level of coat assembly may provide an approach for creating DNA-based hierarchical nanomachines undergoing collective motion upon stimulation by external triggers.In the chapter 2,we show the collective helicity switching triggered by a pH change.Here we report virus-like hierarchical assembly that undergoes repeated collective motion in helicity switching of native DNA and synthetic coat assembly triggered by p H change under physiological conditions.Additionally,the collective helicity inversion of the DNA-coat assembly is also followed by its translocation into intracellular compartments.In the chapter 3,we show some work which we fcous on new.The main reaserch is Aggregation Induction on controllable charged surface of self-assembled sheet.