The Synthesis And Application Of Organic Hypervalent Iodine Compounds

The high iodine reagent as an easy to prepare, moderate performance, selectivity, superior reaction performance and environmentally friendly n ovel organic synthetic reagents are widely used in modern synthetic organic chemistry, causing widespread concern organic chemists. In recent years, a variety of new high-priced organic iodine compound is endless, and exhibits numerous unique, innovative and high-profile response performance. This paper focuses on some of the traditional high-priced organic iodine reagent exploration of new reactions, and actively trying to design, synthesis of a series of new organic hypervalent iodine reagents.Based on a lot of research in the literature, a series of organic high iodine reagents have been synthesized in the paper. Meanwhile further attempts have been taken to explore and design the synthesis of some new high iodine reagents based on the theoretical knowledge on the existing high iodine.And then a transition-metal-free transformation of readily available thioethers into the corresponding thiocyanates through the Csp3-S bond cleavage have been achieved in the paper. This process features relatively broad substrate scopes, less-toxic hypervalent iodine reagents, mild operating condit ions, excellent functional group compatibilities, and affords various thiocyanates in moderate to good yields. Notably, this protocol is not only complementary to existing methods of thiocyanate formation, but also offers an opportunity to extend the appli cations of less-toxic hypervalent iodine reagents in organic synthesis.