Synthesis And Spectral Properties Studies Of Novel 5-meso-modified Tailed Porphyrin

The porphyrin conjugated system has a large rigid planar aromatic ring structure with good electron mobility in the ring, meanwhile, there is a strong absorption and excellent electrical characteristics in the visible region, and there are many unique physical and chemical properties. Since the porphyrin ring plane compound has the advantage of easy modification, therefore, many new compounds can be prepared which have broad application prospects in photodynamic chemotherapy, biological probes and bio-imaging, etc by selectively modified the simply porphyrins. This paper mainly studied the following two aspects:1 As 3,4-dihydropyrimidone and their derivatives(DHPM) are important drug intermediates with special therapeutic properties and pharmacological activity, according to the principle of drug design split, DHPM derivatives are used to modify porphyrin ring in this paper. Ten kinds of new DHPM modified tailed porphyrin and their zinc complexes are synthesized in this paper in order to reach the purpose of improveing the photodynamic chemotherapy photosensitizer drug actives. It was confirmed that the tailed active groups DHPM coordinate with zinc in zinc porphyrin complexes by diffraction method, we also hypothesized that the porphyrin ring was distorted due to the stretching coordinated bond, and all new compounds were characterized by 1H NMR, 13 C NMR, HR-MS, IR and other methods.2 As porphyrin has a good property of tissue penetration and is a natural fluorophores, according to the mechanism of electron transfer photoinduced, a new near-infrared fluorescence probe containing 2,4-nitrobenzenesulfonyl-modified tailed porphyrin which can be used in sulfide anion detection is prepared in this paper. The probe with high sensitivity, high selectivity can carry out the fluorescence detection of sulfur ions, at the same time, it has been successfully applied into live cell imaging of S2-. Compared with the conventional small molecule organic fluorescent probes, the fluorescent probe with a longer emission wavelength(λem> 650nm) can trace sulfur ions to achieve high sensitivity, high selectivity, high aging in the near infrared region testing, There is a great prospect in the field of the biological and environmental test based on fluorescent probes.