Synthesis, Preparation And Characterization Of Novel Organic Antimicrobial Agentsand Antimicrobial Polymeric Materials

N-halamine compound, which is a new class of organic antimicrobial agents containing one or more nitrogen-halogen covalent bonds, having many advantages such as high efficiency, excellent durability, low toxicity, broad spectrum, good stability, and regenerability. Since the discovery in early twentieth century, the design and synthesis, the antimicrobial mechanismof N-halamine antimicrobial agentsand materials have been comprehensively studied.A series of bis(5,5-dimethylhydantoin) substituted alkyl derivatives(B(DMH)A) were pepared by 5,5-dimethylhydantoin with alkyl bromides with different alkyl lengths(C2 to C12).Upon chlorination, the correspondent N-halamines(Cl-B(DMH)A) were synthesized. Their chemical structures were characterized by magnetic resonance spectroscopy(NMR), fourier transform infared spectroscopy(FTIR), Uv-visible spectroscopy(Uv-vis), thermical analysis(TG&DSC), the oxidative chlorine content in the sample was determined by iodometric/thiosulfate titration. Finally, the antimicrobial properties of these compounds were characterized with Escherichia coli(Gram-negtive bacteria) and Staphylococcus aureus(Gram-positive bacteria). All the samples provided a total kill of the Gram-negative and Gram-positive bacteriain less than 120 min. Thestructure-antimicrobial efficacy relationships of the Cl-B(DMH)A are further discussed.The N-halamine precursor AEP-ADCT with triazine phosphonateswas synthesed based on 2-amino-4,6-dichlorotriazine(ADCT) and diethyl cyanomethylphosphonate(DCMP).Then the structures were characterized by nuclear magnetic resonance spectroscopy(NMR), fourier transform infared spectroscopy(FTIR), thermical analysis(TG&DSC).The chemical graftingwas employed to immobilize AEP-ADCT notocellulosic fabric materials.Upon chlorination, the modified fabric had killed 90% of bacteria in 15 seconds, and its afterglowtime was 2-5s, which was far less than the originalfabric. These show that the multifunctional fabric with antimicrobial and flame retardant properties was successfully prepared.