Investigation On Nanochannel Arrays Based Functional Device And Its Applications

Nanochannel is the pore or tubule with diameter from 0.1 to 100 nanometers. It mainly includes bio-nanochannel and solid-nanochannel which can be classified by single nanopore and nanopore arrays. Now the researchers are getting more interest in solid-nanochannel because of its structural stability, better thermal stability and excellent optical properties in the micro scale. However, there are still many aspects needed to be studied and improved on the theory and the application. Hereby, main works in this present thesis are shown as following:1. About bio-molecular detection:We designed and manufactured three new U-shaped detectors and built the experiment platforms based on these U-shaped detectors. By these experiment platforms, we can get temperature difference, viscosity difference and pressure difference in two cells of the U-shaped detector. Through these experiments, we studied the influence of temperature, viscosity and pressure on the molecular transporting through nanochannel.2. About proteins separation:We designed a new U-shaped cell and build the experiment platform based on this U-shaped cell. The electrical field and pressure can be applied at the same time in the cell. During the single-protein experiment, we can obtain the balance point of protein through regulate the voltage and pressure. Then by using the different balance points of different proteins, at last we finished the proteins separation. We change the pH of the buffer solution to 4, and we study the influence of pH on the protein separation through comparing the result of pH 7 and pH 4.3. About polymer synthesis:Based on the nylon nanochannels membrane, we designed a U-shaped cell and built the experiment platform for synthesis of nano-structured material of polyaniline. Using this experiment platform, we can regulate the scale of the pressure difference between the two sides of the cell and the diameter of the nanopores. Under the different experimental conditions, we can obtain polyaniline with different character. According to the results of characterization, we can obtain rod-shaped polyaniline with certain condition.