Microwave Synthesis, Characterization And DNA Binding Studies Of Transition Metal Complex With Imidazopyridine

The development of the interaction and the application of the imidazopyridine are summary in this paper,it involved interaction modes,research methods and research techniques between the complex and DNA,the development direction and prospects were also expatiated.2,6-bis(iminazole[4,5-b]pyridine-2’-yl)pyridine was synthesized in microwave way by 2,6-pyridine.dicarboxylic acid and 2,3-Diamino-pyridine,the overall yield is 50%and the irradiation time is only 9min.It never saw any report about this complex,it is a new organic complex.The method provides a simple access to the title compound.The method has a characteristic of low energy consumptions and environmental protection.The three complexes of lead(Ⅱ),chromium(Ⅲ),cadmium(Ⅱ)andwith 2,6-bis(iminazole[4,5-b]pyridine-2,-yl)pyridine were synthesized in the conventional condition.In our experiment,we use UV absorption and viscosity measurements to study the interaction between complexes(or ligand)and DNA.The absorbance of the complexes and ligand all decrease,and the emission intensity also increase,but with the increasing of DNA concentration,there are not red shifted in the wavelength.The date of viscosity measurements reveal that the relative viscosity don’t increased obviously with the increasing complex,except the ligand.All this results of these measurements reveal that the presence of ligand has obvious effect on the relative viscosity of DNA.So we can inclue that it’s more stronger interation between the DNA and ligand than the complex.