Studies On Rhodium-Catalyzed Reactions Of Epoxides Or Aromatic Aldegydes With Arylboronic Acids

Aryl boronic acid has good benefits of a low toxicity,stable to air and water,good functional group compatibility.Transition metal catalyzed coupling reactions,such as Suzuki-Miyaura reaction,Heck reaction,Chan-Lam reaction,which has become one of the most effective way to build C-C bond and build C-X bond(X=N,S,O),attracting more and more attention of researchers.epoxy compounds as a three heterocyclic compounds,are likely to occur ring-opening reaction due to strain of ring.Therefore,ring-opening reactions of epoxides,in particular,the regioselective ring opening reactions are a challenging task in the field of organic synthesis.It is hot spots and front in organic chemistry by using optional transition metal catalyst or changing the reaction conditions to get regioselectivity ring-opened products.The thesis is divided into four parts.(1)Research progress in area of transition metal-catalyzed ring-opening reaction of carbon nucleophiles to epoxides,and addition reaction of aryl boron reagents to aromatic aldehyde are reviewed.(2)Rhodium-catalyzed ring-opening raction of arylboronic acids to epoxides is report,The results of the reaction demonstrate that the epoxides undergo rearrangement process.The reaction is generally higher yields and good functional group tolerability.(3)A new catalytic condition is developed in the field of rhodium-catalyzed addition reaction of 4-nitrobenzaldehyde with arylboronic acids.The reaction is generally higher yields and good functional group tolerability.(4)Experimental sections including the experimental procedures,synthesis of starting materials and structure characterization of productsare described.