Studies On The Ring-opening Of Alkynyl Epoxide

In this paper, the ring-opening of epoxides, and the synthesis methods of allenes were introduced, and the methods of acid-catalyzed epoxy alkynes into allenes were researched. Expounded in this article is divided into three chapters, which are summarized as follows:1. Epoxide and its derivatives are important triatomic heterocyclic compounds. Due to their ease of preparation and ready reactivity, epoxides are important starting materials and intermediates in organic synthesis. In addition, high reactivity with various nucleophiles leads to high regioselective and trans-stereospecific ring-opening products. Therefore, they are widely applied in medicine, pesticides, food, household chemicals and so on.2. Allenes, which contain the functional group of 1,2-propadiene, are highly reactive. In recent years, people pay more enthusiasm to the synthesis of allene, not only to improve and extend the scope of application of some classical synthesis allene, but also put forward a novel type of reaction. Using the rearrangement of alkynyl epoxide to synthesis allene is a kind of new method.3. Synthesis and characterization of allenes through acid-catalyed epoxy alkynes. A novel and efficient method of construction of allenes had been found, which included an epoxy-opening, alkyne-attacking, hydroxyl-inducing. The product allenes had been characterized.