Features Of Gamma Oscillation Evoked By Spatial Summation In Mouse Primary Visual Cortex

In mammalian primary visual cortex(V1),there is a larger non-classical receptive field(non-classicalreceptivefield,nCRF)beyond the visual neuron's classical receptive field(classical receptive field,CRF).The interaction of CRF/nCRF is considered as the neural basis of visual perception,which will contribute to understanding image integration in cerebral cortex on studying the interaction between the nCRF and CRF.It is generally considered that rhythmicoscillation in primary visual cortex can bound visual feature,which may be the synchronous integration mechanism of V1 neurons.Some interneurons play an important role in these two mechanisms.Therhythmicoscillation is also associated with the nCRF according to the similarity of the functional connection.However,there are few studies about the relationship between the rhythmicoscillation and the role of n CRF.In this paper,byrecordingneural responsesin mouse V1 by means of neuroelectrophysiological technology called single unitrecording,we aim to studyresearch the potential relationship between the centersurround interaction of CRF/nCRF and rhythmicoscillation.We focus on studyingthe intercellular communication and synchronization to understand the effect of rhythmicoscillationon the image information processing process.In our experiment,64 cells were collected in C57BL/6mouse V1.According to the area integration characteristics,these V1 cells were divided into inhibitory nCRF and facilitatory nCRF cells.Two frequency peaks were observed in V1 neural oscillation in this experiment,one peak was at 20-30Hz(beta oscillation)and another peak was at 30-60Hz(gamma oscillation),our result suggestedthat there was no fixed relationship between oscillationamplitudeand peak frequency in V1 beta oscillation(49/60)and gamma oscillation(42/48).Ourresults from power spectrum analysis of rhythmic oscillation showed that the relationship between the power of rhythmic oscillation and stimulus area is related to the area integration of different type: Ifthe neuron's nCRF is inhibitory,most of beta(36/48)and gamma(26/34)oscillation is also inhibitory.On the contrary,if the neuron's nCRF is facilitatory,most of beta(7/13)and gamma(8/14)oscillationsare also facilitatory.From the above results,we speculated that beta and gamma oscillations in V1 require inhibitory local driving fromsurround inhibitory interneurons in nCRF.Moreover,the nCRF couldnot only modulate the cellular responses in CRF,but also made a difference in beta and gamma oscillation.