| The semiconductor materials with their unique structure and excel ent physical and chemical properties are of great concern to researchers. Copper chalcogenide as a kind of important semiconductor nanocrystal, due to its superior performance in the fields of photoelectricity and thermology, become the hot material in recent years. This kind of semiconductor material with low-priced, morphology diversity and good biological compatibility is widely used in bio-sensing, catalysis, solar cell and biomedicine. In addition, the copper chalcogenide exhibit strong localized surface plasmon resonance(LSPR)properties in the near infrared region(NIR). The LSPR of copper chalcogenide is caused by defects in copper free carrier(hole), which is different from that of noble metal materials generated by the free electrons. Based on its outstanding LSPR in NIR, copper chalcogenide can convert light into heat and have been widely used in the minimal y invasive tumor treatment technology of photothermal therapy( PTT) and photodynamic therapy(PDT).At present, most synthetic methods of copper chalcogenide are high cost and timeconsuming. The products are poor dispersion in aqueous solution and difficult to be modified, which limit their applications in biomedicine. Therefore, the research in the improvement of synthetic methods is very essential. This study focuses on above difficulties and refers to previous research results, and concrete work as follows:(1) A surfactant assisted solvothermal method for controllable synthesis of the ternary Cu2-x Sy Se1-y al oy material was fabricated. The research includes three aspects: 1) by surfactant assisted solvothermal method, ternary Cu2-x Sy Se1-y micro-flower al oy material was successful y synthesized and its properties were further studied. 2) The influences of different reaction conditions on the particle sizes and shape of Cu2-x Sy Se1-y al oy material were investigated, especially the morphology evolution of the Cu2-x Sy Se1-y. 3) Due to the ternary al oy material with broad absorption band and larger specific surface area, the cationic fluorescent dye rhodamine 6G could interact with the al oy materials and further constructed an “off-on” detection system for the sensitive analysis of sulfhydryl compounds in the blood.(2)Based on a simple redox reaction, the nonstoichiometric Cu2-x Se NPs were in situ produced on the surface of CNTs at room temperature and detailed characterizations of the nanohybrids were carried out. The experimental results suggested that Cu2-x Se/CNTs with good water-dispersion and strong localized surface plasmon resonance absorption in NIR. Meanwhile, the LSPR of Cu2-x Se/CNTs could be adjusted by controlling the reaction conditions. Based on its LSPR, the study further focused on the photothermal conversion efficiency of the nanohybrid. The results shown that the photothermal conversion ability of Cu2-x Se/CNTs is better than that of single Cu2-x Se NPs and CNTs. In addition, its well biocompatibility was also conducive to the further application in biology. Finally, the nanohybrid was successful y applied for the photothermal treatment in vitro. Compared with single Cu2-x Se NPs and CNTs, the combination of two different type’s materials exhibited significantly enhanced photothermal therapy effect.Based on above experimental results, we develop a surfactant assisted solvothermal method to controllably synthesize the flower-like ternary Cu2-x Sy Se1-y al oy materials. The Cu2-x Sy Se1-y with excel ent physical and chemical properties and further used for the analysis of biological molecules. By simple oxidation and reduction reaction, the Cu2-x Se NPs were successful y in situ synthesized on the CNTs at room temperature. Compared with the single Cu2-x Se NPs and CNTs, the Cu2-x Se/CNTs nanohybrid show outstanding photothermal conversion performance and an attempt was further made to its application in photothermal therapy. |
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