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Research Of The LSPR Biosensor Integrated With Silver Nanoparticle Array And Travelling Wave Valveless Micropump

Posted on:2016-04-24Degree:MasterType:Thesis
Country:ChinaCandidate:W X YeFull Text:PDF
GTID:2308330461480532Subject:Microelectronics and Solid State Electronics
Abstract/Summary:PDF Full Text Request
With the development of nanomaterial technology and microelectronic mechanical system (MEMS) processing technology, the chip of optical biosensor which has high detection sensitivity become a current research hot spot. This article is to study and construct the chip of optical biosensor integrated with silver nanoparticle localised surface plasmon resonance array and travelling wave valveless micropump which used in the field of biomedical. The main research work includes:1、Propose a travelling wave valveless micropump based on the rotating magnetic micro array as traveling wave actuator. Theoretically analyzes the formation mechanism of traveling wave on the elastic microchannel. Using the theory of micro flow fluid properties to analyze several important factors of the microchannel that affect the working performance of the micropump and make an optimized improvement.2、The fabrication process of travelling wave valveless micropump. First, using the organic glass (PMMA) as material and MEMS processing method to construct the base of micropump and the mould of microchannel; Then, inject the liquid polymer PDMS to the mould of microchannel. After a curing processing, an elastic microchannel was fabricated; Next, using hot bonding technology to package the microchannel to the base of the micropump; Finally, installing the micro permanent magnet array on the up base of the micropump. This was the complete fabrication of the travelling wave valveless micropump. The microchannel was designed as a multilevel diffusion structure which improved the maximum average flow rate and back pressure under the low driving voltage.3、Propose a rapid, simple and ease hydrothermal preparation method for synthesis of silver nanoparticles. The morphology and optical properties of silver nanoparticles were characterized by transmission electron microscope (TEM), atomic force microscope (AFM), X-ray diffraction (XRD) and uv-vis spectrophotometer (UV-VIS). Besides, useing the formation silver nanoparticles self-assembly on glass substrates as the front-end sensing unit.4、The fabrication of the optical biosensor integrated with silver nanoparticle localised surface plasmon resonance array and travelling wave valveless micropump. With the silver nano LSPR array as a detecting probe and using MEMS processing method to combine the micropump and silver nano LSPR array into the PMMA substrate; And fix optical fiber over silver nano LSPR array; Then, link the optical fiber and piece of spectrophotometer which was used to detect the change of LSPR extinction spectra.5、Vegetable protein molecules (ConA) measurement applications. Using the traveling wave valveless micropump to drive the solutions of different concentration of ConA to the pool which was fixed with silver nano LSPR array. The determination of the concentration of LSPR extinction spectra was used to verify the detection performance of this biosensor.
Keywords/Search Tags:Localized Surface Plasmon Resonance, Travelling wave valveless micropump, Microfluidic chip, Silver nanoparticle, Optical biosensor
PDF Full Text Request
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