A Research On The Effects Of Sodium Salicylate On The Energy Sources Of Skeletal Muscle And Its Mechanism

Purpose:The change of the mice’s skeletal muscle glycogen, free fatty acids, and free amino acids after injected with sodium salicylate (dose from10mg/kg to50mg/kg) was studied in this paper. There were compare groups of quiet and exhausted state of the mice. The influence of slight dose of sodium salicylate to mice’s skeletal muscle energy substances was demonstrated, which provided experimental support for its development and scientific use in the fields of sports.Methods:The study objects were120male Kunming male mice. After one-week feeding, and an adaptive swimming, they were randomly divided into12groups, including the normal quiet group, the normal exhaustive group, experiments quiet group I, experimental exhausted group I, experiments quiet group II, experimental exhausted group II, experiments quiet group III, experimental force dried group III, experimental quiet group Ⅳ, experimental exhausted group Ⅳand experimental quiet group V, exhaustive experimental group V,(n=10). After the entire normal quiet group, we will take the quadriceps one hour. After each exhaustive group took medicine one hour later, we will take exhaustive swimming and recorded swimming time. Then the quadriceps was used for testing skeletal muscle glycogen, free fatty acids, and free amino acids.Results:(1) In exhaustive mice groups experiment, exhaustive swimming time of normal exhaustive group was significantly higher than the other groups.(2) Exhaustive exercise before and after skeletal muscle glycogen levels are significantly different (P<0.01). Resting state, the experiment quiet mice skeletal muscle glycogen content was lower than the normal quiet group. Exhaustive experiment (administration), exhausting mice exhausted instantly skeletal muscle glycogen content was higher than normal exhaustive group.(3) The group before and after exhaustive exercise in skeletal muscle of free fatty acid content in addition to experimental group Ⅲ, significant differences in other groups (P<0.01). Quiet State, the content of free fatty acid in skeletal muscle of mice with experimental silent group is higher than the normally quiet group. When exhausted, exhaustive set of experimental skeletal muscle in mice are below normal strength exhaustive set of free fatty acid content, only experimental exhaustive V is higher than normal exhausted group.(4) The group before and after exhaustive exercise in skeletal muscle of total amino acid content in addition to experimental group I, other groups have significantly different (P<0.01). Quiet State, the micewith experimental silent group amino acid content is higher than normal quiet unit of skeletalmuscle. When exhausted, experimental mice with exhaustive set of total amino acid content ishigher than normal skeletal muscle exhaustion group, only below normal strength exhaustiveset of experimental exhausted I group.Conclusions:(1) Normally, the major consumption is muscle glycogen during the exercise.When injected into the trace of sodium salicylate, the consumption of movement is free fattyacids. This phenomenon indicates that sodium salicylate can promote fat mobilizationdecomposition of free fatty acids to provide energy and reduce consumption of muscleglycogen in the movement to prolong the exercise time and improve the athletic ability of thebody.(2) Due to trace amounts of sodium salicylate fat produced from the decomposition oflarge amounts of free fatty acid in skeletal muscle, not only reduces the body’s muscleglycogen depletion. While, we will also reduce the mobilization of a protein during exercise,and provide raw material for Gluconeogenesis and protein synthesis.(3) The study also findsthat the storage of free fatty acids is more useful than muscle glycogen storage of body in theenergy supply system.