Study On The Preparation And The Quality Standards In Fanbing Nanoemulsion

Objective:Through the research of prescription screening process and quality standards for fanbing nanoemulsion, it provides basises for preparation and quality control on a new type of treatment for burns, sclads.Methods:Through the analysis of nanoemulsion composition, it determines the preparation methods, through the appearance of traits as an index, it optimizes the prescription blank nanoemulsion composition;Through solubility experiments, different emulsifier selection and phase diagram drawn,using the the appearance of emulsion morphology and particle size of emusion droplet as indexes of fanbing nanoemulsion to choose the oil phase and non-ionic surfactant, optimizesd the best prescription of fanbing nanoemulsion; Using the appearances as an indicator to determine the final preparation process of fanbing nanoemulsion; done by TLC Identification; using Gas Chromatography(GC) determination, and methods of inspection. the blank nanoemulsion is that ethyl oleate: OP-10=1:2. the best prescription for the fanbing nanoemulsion is ethyl oleate:OP-10=1:3. The preparation process of fanbing nanoemulsion as follows:weighing borneol of the prescription volume, adding appropriate amount of ethyl oleate and emulsifier,dissolving borneol, borneol:ethyl oleate:OP-10=5:8: 24,while stirring,dropwising water to 600ml, then add 400ml water dissoluted the prescription volume of baifan, NaCl into nanoemulsion, mixing and filtering under atmospheric pressure, sealing, rolling aluminum cover,116℃sterilization 40min. Borneol TLC negative non-interference, Borneol and isoborneol, aquifer potassium aluminum sulfate method for the determination is feasible and good repeatability.Conclusion:Preparation of viable, reliable quality standards and can be used for industrial production.