Meta Analysis Of The Diagnostic Accuracy Of Osteopontin For Malignant Pleural Mesothelioma

Objective: To investigate the diagnostic value of osteopontin for malignant pleural mesothelioma(MPM).Methods: Using appropriate keywords, qualified studies published in English till March 05, 2016 on evaluation of circulating levels of osteopontin for the diagnosis of MPM were retrieved from Medline, Embase and The Cochrane Library datebases. The tool of QUADAS-2 was used by two reviewers to assess the quality of the studies. The total sensitivity, specificity and diagnostic odds ratio of OPN in the diagnosis of MPM were obtained by using the random effect model. The total diagnostic performance of OPN was evaluated by summary receiver operating characteristic curves(SROC) approaches.Results: A total of 7 studies were included in the analysis. The summary estimates as follows: Sensitivity was 0.59(95% confidence interval: 0.54-0.63), specificity was 0.85(95% confidence interval: 0.83-0.87), diagnostic odds ratio was 10.63(95% confidence interval: 7.73-14.60). The area under curve(AUC) was 0.8390 with Q value of 0.7709.Conclusions: OPN may be an effective marker for the diagnosis of MPM. In view of the limited studies and patients included, more research is required to verify these findings.