A META-analysis Of Effect Of Drug-eluting Balloons Versus Dtug-eluting Stents In The Treatment Of Stent Restenosis

Objective To evaluate the safety and efficacy of the drug-eluting balloon compare drug-eluting stents in the treatment of Patients With In-Stent Restenosis.Methods A Meta-analysis was conducted by searching Medline, Embase, Cochrane, Articles, VIP(VIP), China National Knowledge(CNKI) and other databases, supplemented by other search methods to retrieve all relevant drug-eluting stent in the treatment of drug-eluting balloons contrast stent Restenosis randomized clinical trial(RCT). Statistical analysis by RevMan5.3.Results The final included six randomized controlled trials [5-10], a total of 1153 patients were included in the study, at a minimum lumen diameter(standard mean difference of-0.12(95% CI =-0.20 ~-0.05, P = 0.002)) between the two groups was statistically significant, but the rest of analysis indicators(Late lumen loss, Binary restenosis, Target lesion revascularization,Myocardial infarction,Death) had no statistically significant difference.In the subgroup of Everolimus-Eluting Stents,minimum lumen diameter(standard mean difference of-0.25(95% CI =-0.36 ~-0.14, P <0.00001)), Late lumen loss(standard mean difference of-0.11(95% CI = 0.01 ~ 0.20, P = 0.03)), Binary restenosis(RR = 1.79(95% CI = 1.08 ~ 2.99, P = 0.03)), Target lesion revascularization(RR = 0.05(95% CI = 0.01 ~ 0.10, P = 0.03)) difference was statistically significant.Conclusion Overall, in terms of the treatment of in-stent restenosis, the drug balloon is not inferior to the stent, but everolimus stent seems to be a better choice.