Analysis Of 456 Cases Of Intrahepatic Of Pregnancy And Hypercholanaemia Of Pregnancy

Objective: To investigate the difference between hypercholanaemia of pregnancy(HP) and intrahepatic cholestasis of pregnancy(ICP).Methods: 82 cases of HP patient and 374 cases of ICP patient were collected from the First Affiliated Hospital of Chongqing Medical University, and 300 cases of normal pregnant women were chosen as a control group. The perinatal outcomes were compared among ICP groups、HP groups and the control.Results:(1) Both ICP group and HP group presented significant higher rates of cesarean section and meconium-stained amniotic fluid when compared to control. The preterm delivery rate was also higer in ICP group than contol. The number of cesarean section and preterm delivery in HP group were found lower than ICP group.(2)In ICP group, the cases of esarean section, preterm delivery and meconium-stained amniotic fluid occurred were significantly higher in the subgroup 1 which maternal total bile acid(TBA)≥40μmol/L than subgroup 2 with maternal TBA between 10μmol/L and 40μmol/L. However,Whatever maternal serum total bile acid,no difference of prenatal outcomes was found in HP group.(3)The cases ofpreterm delivery and meconium-stained amniotic fluid in ICP patients with jaundice were statistically significantly higher than ICP patients without jaundice.(4)Lower level of Alanine transaminase(40<ALT<250) in ICP patients was correlated with lower rate of preterm delivery when compared to ICP patients with higher ALT level( ALT over 250U/L).Conclusion: There is an obvious difference between HP and ICP,not only in maternal serum biochemistry parameters but also the perinatal outcomes.The HP patient has better outcomes than ICP. Maternal serum total bile acid, bilirubin and liver enzyme should be considered when assessing the severity of ICP and evaluating pregnant outcomes.