Study Of The Correlation Between Intrahepatic Cholestasis Of Pregnancy And The Morbidity Of Early Neonatal Hyperbilirubinemia

Objective: To study the incidence of intrahepatic cholestasis of pregnancy (ICP) and theimpact on the newborns, and investigate the correlation between ICP and the incidence ofearly neonatal hyperbilirubinemia.Methods:We had218parturient as samples from Affiliated Hospital of Zunyi MedicalCollege, in which there were57cases of newborns and parturient with ICP as an obser-vation group and161cases of normal parturient and their newborns as a contrast group.We recorded all parturient age, gestational age, gravidity and parity history, delivery modes,newborns weight, feeding pattern, premature birth, premature rupture of membranes,asphyxia or fetal distress, meconium stained amniotic fluid, and amniotic fluid volume. Wemonitored bilirubin of newborns (born in a week) with BB-meter Babies Bilirubin Meterdynamically, and reexamined by peripheral blood tester several times.Results:(1)Comparing observation group and contrast group, there’re no differences inage, gestational weeks, gravidity and parity history (P>0.05)；(2)The levels of Serum totalbile acid (TBA)、total bilirubin (TBIL)、bilirubin direct (DBIL)、alanine transaminase(ALT)、aspartate aminotransferase (AST) of ICP parturient were obviously higher thanthose of contrast group(P<0.05)；(3)The incidence of caesarean section、meconium stainedamniotic fluid、neonatal asphyxia、premature birth and perinatal death in ICP respectivelywere78.59%、22.81%、17.54%、26.32%and8.78%, while contrast group respectively were56.62%,8.07%,5.64%,4.35%,0.62%,(P<0.05)；besides, there’re no differences betweenobservation group and contrast group in newborns weight, onset and the incidence ofneonatal hyperbilirubinemia, and premature rupture of fetal membranes.(P>0.05)；(4)Itshowed the incidence of early neonatal hyperbilirubinemia in observation group was muchhigher than in contrast group, in which respectively were35.10%and10.56%,(P<0.05).The incidence of neonatal hyperbilirubinemia among premature infant was much higherthan it among term infant in contrast group,(P<0.05)；(5)The incidence of neonatalhyperbilirubinemia of neonatus by natural childbirth was much lower than neonatus by cesarean delivery, respectively,16.67%,40.00%,(P＜0.05)；(6)There was a positivecorrelation between the incidence of early neonatal hyperbilirubinemia in ICP and thelevels of serum TBA、TBIL、DBIL of their mothers, respectively, r=0.384,0.301,0.308,(P＜0.05).Conclusion:(1)The incidence of early neonatal hyperbilirubinemia is much higher in thenewborns of ICP parturient.(2)The high concentration of bile acid、bilirubin,prematuredelivery, cesarean delivery and fetal hypoxia might be relate to the early neonatalhyperbilirubinemia in ICP.