Retrospectively Analyzed The Characteristics Of Benign And Malignant Thyroid Nodules In Chongqing Region

Objective: To provide some basis for nature of thyroid nodules we analysis the clinical characteristics of benign and malignant thyroid nodules.Methods: We collected 292 cases of hospital patients who had thyroid surgical treatment from January 2015 to December 2015 in the Second Affiliated Hospital of Chongqing Medical University. That we collected were general conditions, thyroid function, thyroid autoantibodies,thyroglobulin and the characteristics of thyroid ultrasound. The groups were divided into benign and malignant group according to the results of pathologic examination. We analyzed clinical data including age, gender,symptoms, touch rate, TSH, FT3, FT4, Tg Ab, TPOAb, Tg, and the characteristics of thyroid ultrasound using SPSS 20.0 statistics software and retrospective analysis.Results: 1.In 292 cases(benign 229, malignant 63), the benign andmalignant percentage were 78.42% vs. 21.58%.Follicular neoplasia wasthe most in benign group and papillary carcinoma was the most inmalignant group.2.The average age in malignant group was younger than benign group(46.97±13.04 vs.50.97±13.84, P<0.05).The difference had no statistically for gender in groups.3. The difference had no statistically for uncomfortable symptoms in groups. The touch rate in malignant group was smaller than benign group(34.92% vs. 58.52%, P<0.05).4.The serum TSH level in malignant group was higher than benign group(2.29±0.62 vs. 1.87±0.48, P<0.05), the higher of serum TSH level the larger of malignant rate. The difference had no statistically for FT3, FT4,Tg in groups.5. The Tg Ab positive rate in malignant group was higher than benign group(11.76% vs. 3.78%, P<0.05), the TPOAb positive rate in malignant group was higher than benign group(21.57% vs. 6.01%,P<0.05), the Tg Ab and TPOAb both positive in malignant group was higher than benign group(7.84% vs. 1.63%, P<0.05).6.The average diameter in benign group was bigger than malignant group(2.63±0.46 vs.1.7±0.38, P<0.05).The difference had statistically significant(P<0.05)for ultrasonic characteristics including low echo, blood flow signals within nodules, calcifications, boundary, form and cervical lymphadenectasis and no statistically significant(P>0.05) for quantity and blood flow signals surrounding nodules. 7.Lymph node metastasis was associated with lymphadenectasis(P<0.05).8.Independent risk factors of benign and malignant thyroid nodules were age, TSH, TPOAb,low echo, size, blood flow signals within nodules, calcifications,boundary, form and cervical lymphadenectasis through the binaryLogistic regression analysis.Conclusion:1. In order to early detection and identification, we should pay attention to population screening for thyroid nodules.2.Younger patients,high serum TSH level, thyroid autoantibodies and are more common in the malignant group. The higher serum TSH level is,the larger malignant rate. Autoimmune thyroid diseases may be correlated with the nature of thyroid nodules.3.Ultrasound characteristics include low echo, blood flow signals within nodules, calcifications, boundary, form, and cervical lymphadenectasis are the most in the malignant group.