Progress In Osteosarcoma Treatment Research

Osteosarcoma is the most frequent primary malignant bone tumor,which predominantly occurs in childhood and adolescence.Because of its high-malignant degree and poor prognosis,osteosarcoma brings about a tremendous mental and economic burden to our family and society.As the adjuvant and neoadjuvant chemotherapy is put forward,the five-year survival rate of the patient has got close to approximately 60%~70% and the quality of life,especially for the teenager,has ameliorated a lot owing to the improvement of the limb salvage rate.The treatment of osteosarcoma has been staying in a plateau recent years though clinician now has more options than before such as immunotherapy,gene therapy,biological target therapy,et al.Multi-drug resistance is to blame for this development bottleneck as well as lack of standardization of those new therapies.Therefore, it’s time to do some further researches at the level of genes in order to know more about some special gene target spots in regard to the origin and mutation of osteosarcoma.This article is to make a review about some cutting-edge progress in the treatment of osteosarcoma combining with our own discovery that ferulic acid inhibits proliferation of osteosarcoma cells and induces apoptosis.