Clinical Observation Of Conventional Treatment Combined With Montelukast On The Treatment Of Infantile Asthma

Objective: To investigate the clinical effect of conventional treatment combined with Montelukast on the treatment of infantile asthma.Methods: 60 cases with infantile asthma, which admitted in our hospital during December2014 to June 2015, were selected as the research object, the diagnosis were in line with the "Chinese children asthma guidelines 2008" standard. Other diseases such as throat disorders,congenital malformation, airway foreign bodies, tuberculosis identification with asthma were excluded and test drug allergies and Montelukast treatment within two weeks were excluded.All cases were randomly divided into control group and treatment group, 30 cases in each group. Two groups of children with acute phase were given conventional treatment stopping coughing, and inhaled bronchodilator spasmolysis and hormone therapy and anti-inflammatory treatment for the merge infection. Treatment group on the basis of routine therapy, combined with Montelukast chewable tablet(singulair, Hangzhou MSD co., LTD.,production) oral treatment, < 2 years old 3mg, 2~6 years old 4mg, above 6 years old 5mg,once-daily oral before sleep. Two groups’ symptoms and signs improvement and asthma score changes after 7 days, 14 days, and 21 days were observed and analyzed.Results: asthma symptom scores in the two groups were compared, there was no statistically significant difference( P > 0.05). Curative effect before and after the treatment of the control group and treatment group were compared and the asthma symptom scores of two groups were decreased significantly after treatment, differences had statistical significance, F =18.188, P < 0.05. Two comparison shows: comparison difference before and after treatment 14 days and 21 days of the control group was statistically significant, P < 0.05; 7days 14 days, 21 days three time points of treatment group after treatment, comparative differences were statistically significant, P < 0.05. Grouped according to child family from the factory, symptoms of total credit period of two groups were compared and the results show that the factory close group total credit period was lower than the distance from the factory group, difference was statistically significant, t = 11.843, P < 0.05.Conclusion:1. On the basis of conventional treatment combined with Montelukast oral therapy can significantly improve the patient’s symptoms of asthma.2. Montelukast short-term treatment of asthma symptoms improvement is not obvious, at least2 weeks of long-term treatment curative effect is better.3. The family of petrochemical factory close with curative effect is poorer; treatment of asthma in this region may be affected by air pollution.