| Objective: To discuss infection of Borna Disease Virus(BDV) in patients with Viral Encephalitis(VE) from unknown causes in Xingyi region of Guizhou province by reviewing clinical features of these VE-positive patients with BDV circulating immune complex(CIC) or antibody.Methods: From Oct.2013 to Oct.2014, the cerebrospinal fluid(CSF) and peripheral blood were collected from 54 patients with VE from unknown causes in Xingyi, namely People’s Hospital of Southwest Prefecture and People’s Hospital of Xingyi. The 54 cases VE were experimental group, in which 30 cases were male and 24 cases were female, from 15 to 70 years old and the average age was 38.4±6.03 years old. On the other hand, the CSF and peripheral blood were collected from 48 patients with non-inflammatory neurological diseases(namely cerebral trauma) in Neurosurgery Department of People’s Hospital of Xingyi. The 48 cases are control group, in which 28 cases are male and 20 cases are female, from 14 to 68 years old and the average age is 32.6±5 years old. Enzyme Linked Immunosorbent Assay(ELISA) was employed to detect BDV CIC and antibody in samples of CSF and plasma of 54 patients of the experimental group and 48 patients of the control group.Results: In 54 patents of the experimental group, 7 were BDV CIC positivein their CSF, so its positive rate was 12.96%(7/54). In contrast, no one was BDV CIC positive in their CSF in the control group and its positive rate was 0. Therefore, the positive rate of experimental group was significantly higher than the rate of control group, there was significant difference between two groups(P<0.05).While 5 were CSF BDV antibody positive in the experimental group and its positive rate was 9.26%(5/54), no one was CSF BDV antibody positive in the control group and its positive rate was 0,the positive rate of experimental group was significantly higher than the rate of control group, there was significant difference between two groups(P<0.05). On the other hand, 12 were BDV CIC positive in their plasma in the experimental group and its positive rate was 22.22%(12/54), while no one was positive in their plasma in the control group and its positive rate was 0. Hence, the positive rate of experimental group was significantly higher than the rate of control group, there was significant difference between two groups(P<0.05). While 5 were BDV antibody positive in their plasma in the experimental group and its positive rate was 9.26%(5/54), no one was BDV antibody positive in their plasma in the control group and its positive rate was 0, the positive rate of experimental group was significantly higher than the rate of control group, there was significant difference between two groups(P<0.05). Though BDV CIC positive rate in the plasma was higher than in the CSF, it was not statistically significant(P>0.05). In addition, 3 cases were BDV CIC positive in the CSF and the plasma,3 cases were both BDV CIC positive in the plasma and BDV antibody positive in the plasma, and 3 cases were both BDV CIC positive in the plasma and BDV antibody positive in the CSF. In sum, 16 cases were BDV positive. VE patients with BDV positive generally appeared as mental and behavior disorder.Conclusion: BDV infection exists among VE patients in Xingyi, Guizhou province and could account for patients with VE from unknown causes. The clinical features of VE patients with BDV infection are characterized by mental and behavior disorder. |
