Meta-analysis Of Risk Factors Of Neurological Complications After Allogeneic Hematopoietic Stem Cell Transplantation

Objective To analyze the risk factors of neurological complications after allogeneic hematopoietic stem cell transplantation.Methods Search through CNKI、Wanfang database、CBM and Pubmed to find all relevant medical publications, Meta-analysis results were estimated using fixed effect model or random effect model.Results Fifteen studies were included, concerning 272 cases and 2169 controls. The overall results suggested that alternative donor(OR=2.95,95%CI=2.04-4.26), haploid transplantation(OR=2.54,95%CI=1.53-4.24),non-genetic transplantation(OR=1.92, 95%CI=1.29-2.85),umbilical cord blood transplantation (OR=3.02,95%CI=1.81-5.04), acute graft versus host disease>Ⅱ (OR=5.88,95%CI=1.86-18.60)were associated with increased incidence of neurological complications after allogeneic hematopoietic stem cell transplantation(P< 0.05). Gender, primary disease, total body radiation, Busulfan were not associated with increased incidence of neurological complications after allogeneic hematopoietic stem cell transplantation (P>0.05).Conclusion Alternative donor, haploid transplantation, non-genetic transplantation, umbilical cord blood transplantation, acute graft versus host disease>Ⅱ were risk factors of neurological complications after allogeneic hematopoietic stem cell transplantation.