Investigation Of Relative Risk Factors About Mothers And Their Infants Born In HBV

Objective:The study is drawn up by the Jincheng city in Shanxi province HBs Ag-positive mothers and their infants born to conduct in-depth epidemiological investigations, to explore the status and risk factors associated with HBV transmission, prevention and control of HBV transmission between mother and child provide clues and basis. Methods:We choose 160 cases of pregnant women in Two hospitals in Jincheng city from January 2014 to January 2015, the women carry the role of HBV subjects as the observation objective. By the method of case-control study, the status of HBV transmission and mother to child transmission of hepatitis B virus potential risk factors were studied, including pregnant women, blood HBV-DNA level, maternal blood of hepatitis B virus e antigen(HBeAg) status, prenatal passive immunization with hepatitis B immune globulin and efficient mode of delivery of pregnant women, feeding their newborns injection of hepatitis B immune globulin immune efficient blocking hepatitis B virus. Result:The results met the inclusion criteria for pregnant women with asymptomatic HBV carriers produced 160 neonates 160 cases in 6 months of age(7-12 months) follow-up serum HBV markers HBsAg, positive in 9 cases, mother to child transmission rate was 5.63%(9/160).Mother HBVDNA> 106 copies / ml group, infants HBsAg positive rate was significantly higher than the mother HBVDNA <103copies / ml group and 103-106 copies / ml group,the difference was significant(P<0.05);Mother HBeAg-positive HBeAg-positive mothers of infants to mother HBsAg positive rate of HBeAg-negative group, the difference was significant(P<0.05). 71 mother HBeAg positive pregnant women in late pregnancy HBIG injection injected HBIG group, Not injected HBIG infants HBsAg positive rate was 10.87%, injected HBIG infants HBs Ag positive rate was 12.00%, there was no significant difference(P> 0.05); HBe Ag-positive cases, cesarean section group infants HBsAg positive rate and natural childbirth group, no significant difference(P> 0.05).Infants breastfed group HBsAg positive rate was slightly higher than the artificial feeding group, but there was no significant difference(P> 0.05) between the two group.Conclusion:Conclusion for the mother to child transmission of hepatitis B virus mainly HBVDNA> 106 copies / ml, HBeAg positive, feeding patterns and mode of delivery and perinatal transmission of hepatitis B virus correlation is not obvious, the third trimester injected HBIG It does not contribute to reduce mother to child transmission of hepatitis B virus.