The Changes And Significance Of The Pre-thrombosis State Molecular Markers In Patients With H-type Hypertension

Objective:By detecting the vWF,GMP-140,D-dimer and FIB of PTS molecular markers in H-type hypertension patients, simple hypertension patients and normal healthy persons,To observe the changes of the Prethrombotic State in Patients with H-type hypertension, And analysis the correlation of H-type hypertension group, Hcy and prethrombotic state molecular markers, and discuss the relevant principle, so as to provide the basis for the early diagnosis and treatment of thrombotic disease in clinic. Methods:Randomly selected 201 patients with essential hypertension, including 136 patients with H-type hypertension(the group of H-type hypertension), 65 patients with simple hypertension(the group of simple hypertension), and 50 healthy subjects were selected as the control group.The plasma concentrations of vWF, GMP-140, D-dimer and FIB were measured in 3 groups,and the relationship between Hcy and PTS molecular markers in patients with H-type hypertension was studied by multiple linear regression analysis. Results:1.The concentrations of PTS molecular markers in group of H-type hypertension and simple hypertension were higher than group of healthy control(P﹤0.05). H-type hypertension were higher than group of simple hypertension(P﹤0.05).2.Multiple linear regression study manifested that Hcy and PTS markers were significantly negative correlation in patients H-type hypertension after excluding confounding factors. Conclusion:There are obvious variation of the concentrations of PTS molecular markers in patients with H-type hypertension, Among them, the plasma homocysteine level is independent risk factors that influence the change of PTS, which clinical significance is closely related to the Thrombotic events in patients with H-type hypertension.