Determining The Relationship Between The Middle Cerebral Artery Plaque Burden And The Volume Of Intracranial Acute Infarcts Area By High Resolution Magnetic Resonance Imaging

Objective:To investigate the correlation of middle cerebral artery(MCA) plaque burden measured by 3.0T MRI and cerebral ischemic lesion volume.Methods:13 patients stay in Shanxi Dayi hospital from August 2014 to March 2016 with acute ischemic cerebrovascular events were collected and were all eligible for inclusion and exclusion criteria. Accepting criteria:(1) All cases were first acute ischemic brain stroke.(2) Have verify there are acute cerebral ischemic lesions in middle cerebral artery(MCA) territory by brain MRI scan and DWI imaging in our department or the outer court underwent.(3) It is confirmed that there are middle cerebral artery stenosis in stroke side by DSA or CTA or MRA.(4) All patients contains two or more risk factors of atherosclerosis:(1) Disorder of lipid metabolism. Such as high cholesterol, high LDL(standard is: LDL≤130 mg/dl), low HDL(standard is HDL< 35 mg/dl), etc(2)Hypertension.Hypertension standard for high pressure ≥ 140 mmHg or(and) or low pressure ≤ 90 mmHg.(3) Smoking.(4) Obesity. Obesity standard for Body Mass Index( BMI) higher than that of Asian standard normal levels, namely the BMI 23 or higher.(5)Hyperhomocysteinemia.(5) Ipsilateral internal carotid artery stenosis degree is less than50% that confirmed by ultrasound. Excluding criteria:(1) Clinical suspicion of disease because of non- atherosclerosis, such as vasculitis, Moyamoya disease,cerebral artery dissection or cardioembolism, etc.(2) Patients can’t cooperate with MRI, such asrestlessness, claustrophobia, or with MRI contraindications.(3) There are other lesions inside the head. Such as head trauma, central nervous system infections and tumors, etc.(4) The author is not the first onset of stroke such as a history of lacunar infarction. All patients underwent high resolution magnetic resonance imaging(HRMRI) of affected side MCA within 2 week after stroke onset. The ischemic lesion area,the narrowest lumen area(LA),the total vessel area(TVA),the most narrow vessel caliber and the proximal vessel caliber were measured, and the cerebral ischemic lesion volume, wall area(WA),rates of stenosis and the normalized wall index(NWI) were calculated. Using statistical software to analyze the consistency of MCA plaque burden and the acute infarcts volume.Results:11 cases were involved in this study. Strong positive correlation between middle cerebral artery plaque burden and middle cerebral artery ischemic lesion volume of ipsilateral was found(P<0.05),and there was no significant correlation between the middle cerebral artery stenosis rate and the acute infarcts volume(P>0.05).Conclusion:Compared with conventional imaging methods, high resolution magnetic resonance imaging can clearly show the middle cerebral artery vascular wall and quantitative measure the plaque burden of atherosclerotic plaque. With the increasing burden of atherosclerosis plaques in the brain, acute infarcts volume for the first time of acute ischemic stroke occurs will increase, and the MCA vascular stenosis rate has no obvious correlation between the ipsilateral acute brain infarction volume.