To Investigate The Relationship Between The NT In The First-trimester And The Serum Biochemical Markers Of Down’s Screening In The Second Trimester And The Pathological Pregnancy

Objective:To understand the significance of screening the fetal neck thickness(NT) in the early stage of pregnancy and the serological marker screening in the fetus.Discuss the correlation beeween NT value,the second trimester serum alpha fetal protein(AFP),beta human chorionic promote level of gonadotropin(hCG),free estriol(UE3) and hypertensive disorders complicating pregnancy,preterm birth,gestational diabetes mellitus,premature rupture of membrane,fetal congenital malformation.Methods:Retrospective analysis of early pregnancy,fetal neck transparent layer thickness(NT)measurement of 796 cases of pregnant women,the second trimestert Down’s screening of pregnant women 245 cases From January 2014 to December 2014 at the Shanxi dayi hospital obstetrics and gynecology clinic.Grouping according to the NT value and the level of MOM of the serum marker,Compare the abnormal rate of the chromosome and incidence of pathological pregnancy in each group,Using WPS software and SPSS16.0software to analysis the correlation among pathological pregnancy,NT value and of AFP,beta-HCG, uE3 level statistically.Results:1.The detection rate of NT in abnormal fetal chromosome 37.50%(3/8) was higher than that of Down’s screening, and the detection rate was 3.87%(6/155)(P<0.05).2.The incidence of gestational diabetes mellitus,fetal congenital malformation,premature birth.2.rate in NT abnormal group was higher than that in the normal group(P<0.05).The difference in incidence of premature rupture of membrane,hypertensive disorders complicating pregnancy between the two groups was not statistically significant(P>0.05).3.Maternal serum free beta hCG level decreased fetal congenital malformation rate was higher than that of control group,the difference is statistically significant(P<0.05);Compared with the control group,the incidence of premature rupture of membrane,hypertensive disorders complicating pregnancy,premature birth and the incidence of gestational diabetes mellitus were not statistically significant(P>0.05).The incidence rate of premature rupture of membrane,hypertensive disorders complicating pregnancy,premature birth,gestational diabetes mellitus and fetal congenital malformation were higher than that in control group,the difference was statistically significant(P<0.05).4.Maternal serum AFP levels in patients with premature rupture of membrane,the incidence of hypertensive disorders complicating pregnancy,premature birth,gestational diabetes mellitus,fetal congenital malformations was higher than the control group,the difference was statistically significant(P<0.05).The incidence rate of hypertensive disorders complicating pregnancy,premature birth,gestational diabetes mellitus,fetal congenital malformations were not statistically significant(P>0.05).5.Maternal serum uE3 levels in the lower group than in the control group,the incidence of pathological pregnancy was statistically significant difference(P<0.05).Conclusions:1.Early pregnancy NT and the combination of serological markers in the second trimester of pregnancy have important significance in the screening of fetal chromosomal diseases, the significance of early screening of NT is greater, NT screening should not beignored in early pregnanc.2.Whether the second trimester maternal serum free beta hCG levels increased or decreased, it may have significance for prediction of pathological pregnancy.3.Elevation of maternal serum AFP levels during the second trimester of pregnancy may be an indicator for predicting pathological pregnancy.4.Decrease of maternal serum uE3 level during the second trimester of pregnancy may be one of the indexes to predict pathological pregnancy.