The Expression Of ZNF580 And VEGF In Gastric Cancer And Their Association With Clinicopathological And Prognostic Significance

Objective:To investigate the correlation of the expression of zinc finger transcription factor 580(ZNF580) and vascular endothelial growth factor(VEGF) with the carcinogenesis and tumor progression of human gastric cancer. Methods:Immunohistochemical method(SP) was used to detect the expression of ZNF580 and VEGF protein in 144 cases human gastric cancer tissues and paracarcinoma tissues. Results:The positive expression rate of ZNF580 in gastric carcinoma was 63.9%, which was higher than that of para carcinoma tissues 18.8%(P<0.01); the positive expression rate of VEGF protein in gastric carcinoma was 57.6%, which was higher than that of para carcinoma tissues 13.9%(P<0.01).The expression of ZNF580 and VEGF was statistically associated with the grades of differentiation, invasion depth, lymphatic metastasis and TNM stage of tumor tissues(P<0.05) and the positive correlation between the two protein expression appeared in gastric tumor tissue(P=0.005). Univariate survival analysis showed that the over-expresstion of either ZNF580 or VEGF was in inverse correlation with the survival time(P<0.05 and P<0.01,respectively). Cox multiple regression analysis showed that ZNF580 over-expression together in gastric cancer have a worse prognosis(RR=3.154, P<0.05) and VEGF over-expression together in gastric cancer have a worse prognosis(RR=4.094, P<0.05). Conclusion:ZNF580 highly expresses in gastric cancer, and might promote the occurrence and progression of gastric cancer in correlation with VEGF.