| Objective: To analyse prevalence and distribution characteristics of coronary heart disease(CHD) and explore its correlates in the patients with type 2 diabetes mellitus(T2DM) hospitalized first time, so as to provide scientific basis for screening, prevention and controlling of CHD in T2 DM patients.Methods: Medical records of T2 DM patients hospitalized first time in General Hospital and Metabolic Disease Hospital, Tianjin Medical University from May 15, 2012 to May 20, 2013 were retrospectively reviewed. Information including demographic characteristics, medical history, disease family history, behavior, physical examination and laboratory examination data were extracted. The database was established using Epi Data software. Prevalence and distribution characteristics of CHD in T2 DM patients were analysed. A case-control study was carried out, in which T2 DM patients complicated with CHD were treated as case group, and T2 DM patients without CHD as control group, to analyse correlates using non-conditional logistic regression.Results: Total of 872 eligible T2 DM patients were included in present study, of which 460 cases were CHD patients. Prevalence of CHD in T2 DM patients was 52.8%. The prevalence in women was higher than that in men, and prevalence increases with age. The case group included 460 T2 DM patients with CHD and control group included 412 T2 DM patients without CHD, The results of univariate logistic regression analysis showed that older age, female, in marriage, long course of disease, higher systolic blood pressure and diastolic blood pressure, diabetic retinopathy, diabetic nephropathy, peripheral neuropathy, hypertension, cerebrovascular disease, carotid artery atherosclerosis, lower lib artery arteriosclerosis, hypertension family history, family history of coronary heart disease, high level of blood urea nitrogen and serum creatinine were statistically associated with high risk of CHD in T2 DM patients. However, current smoking, drinking, higher fasting blood glucose, increased red blood cells and direct bilirubin were statistically associated with low risk of CHD in T2 DM patients. After adjusting for possible confounders, the associations between the risk of CHD in T2 DM patients and female, in marriage, current smoking, drinking, diabetic retinopathy, diabetic nephropathy, peripheral neuropathy, hypertension, cerebrovascular diseases, lower lib artery arteriosclerosis, increased red blood cells and direct bilirubin were not statistically significant. The associations between the risk of CHD in T2 DM patients and family history of diabetes, body mass index, glycated hemoglobin levels, diabetic foot, lipid metabolism disorders, high blood viscosity, high fibrinogen, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and 24 h urinary albumin, platelet, C reactive protein were not found. After adjustment for age, sex and duration of diabetes, body mass index was related to high risk of CHD in T2 DM patients.Conclusion: The prevalence of CHD in T2 DM patients in the present study was 52.8%. Female T2 DM patients had higher prevalence of CHD than males, and prevalence increased with age. The longer the duration of diabetes was, the higher the risk of CHD is. Older age, long course of disease, high body mass index, systolic blood pressure and diastolic blood pressure, family history of hypertension, family history of coronary heart disease, carotid atherosclerosis, high blood urea nitrogen and creatinine were related with high risk of CHD,while fasting blood glucose was related with low risk of CHD in T2 DM patients. |
