Relationship Between The Serum PGE-2,VEGF Level,VEGF Expression Of Gastric Cancer Tissue And Pathoclinic Features In Patients With Hyperlipidemia

Objective:To detect the difference of the expression level of PGE2 in serum and VEGF in serum and gastric carcinoma tissues between the patients with hyperlipidemia and without hyperlipidemia. To analyse the relationship of VEGF expression in gastric carcinoma tissues and clinical pathological features of the patients with gastric carcinoma.And to discuss the infiuence of the invasion and metastasis of gastric cancer complicated with hyperlipidemia.Methods:The clinical pathological date of 102 patients with gastric cancer who had surgical resection in Tianjin Medical University General Hospital from March 2014 to January 2015 was analyzed. The patients were divided into hyperlipidemia group and non-hyperlipidemia group according to the laboratory test results of blood lipid.The expression of serum PGE2 and VEGF were detected by enzyme-linked immunosorbent assay. The expression of VEGF in gastric carcinoma tissues was detected by SABC immunohistochemical staining.Detecting the difference of the two groups with t-test and chi-square test.Analysis the relationship between VEGF expression in gastric carcinoma tissues and clinical pathological features.Results(1)The gastric cancer patients complicated with hyperlipidemia were accounted for 48.01%(49/102) in all 102 patients.(2)The differences of gender and age composition,the location and the size of gastric carcinoma tissues between the two groups have no statistical significance(P>0.05);and the differences of the degree of differentiation, the depth of invasion, the lymph node metastasis and TNM staging between the two groups have the statistical significance(P≤0.05).(3)Serum PGE2 was 28.268±4.250pg/ml in patients with hyperlipidemia and was 20.436±3.694pg/ml in patients without hyperlipidemia,it had the statistical significance between the two groups(t=9.952,P=0.000).(4)Serum VEGF was 274.436±19.417pg/ml in patients with hyperlipidemia and was 206.290±22.779pg/ml in patients without hyperlipidemia,it had the statistical significance between the two groups(t=16.195,P=0.000).(5)The rate of high expression of VEGF in gastric carcinoma tissues was 75.51% in patients with hyperlipidemia and was 28.30% in patients without hyperlipidemia, it had the statistical significance between the two groups(χ2=22.706,P=0.000).(6) There was a positive corelation between the lipid level and the expression of serum PGE2,the expression of serum PGE2 and the expression of serum VEGF(r=0.62,P=0.000); and there was a positive corelation between the expression of serum PGE2 and the expression of VEGF in gastric carcinoma tissues(t=3.441,P=0.001), the expression of serum VEGF and the expression of VEGF in gastric carcinoma tissues(t=4.266,P=0.000).(7) The expression of serum VEGF and the expression of VEGF in gastric carcinoma tissues were not associated with the the patient’s gender and age,the location and the size of gastric carcinoma tissues(P>0.05);and were associated with the degree of differentiation, the depth of invasion,the lymph node metastasis and the TNM staging(P≤0.05).Conclusion:(1)The expression of PGE2 in serum and VEGF in serum and gastric carcinoma tissues were higher in patients with hyperlipidemia than the patients without hyperlipidemia.(2)The higher VEGF expression in serum and tumor tissue can accelerate the process of invasion and lymph node metastasis.(3) There was a positive corelation between the expression of serum PGE2 and the expression of VEGF and infiuence the process of invasion and lymph node metastasis indirectly.(4)It could accelerate the process of invasion and lymph node metastasis via the expression of PGE2 and VEGF in patients with hyperlipidemia.