Meta Analysis: The Efficacy Of Rabeprazole-based Triple Therapy For H.pylori Infection With Different Courses

Objective: In order to objectively evaluate the efficacy of rabeprazole-based triple therapy for the treatment of H. pylori infection with different courses including 7 days, 10 days, and 14 days.Methods: Databases of VIP database, Wanfang database, CNKI, Pub Med were searched for the related literature on rabeprazole-based triple therapy treating H. pylori infection in different courses. The useful data was analyzed by Rev Man statistical software Manager 5.2.Results: With rabepaazole-based triple therapy, the H. pylori eradication rates were higher in 10-day-course and 14 –day-course than in 7-day-course(7d vs 10d: OR 0.72,95%CI 0.53~0.96,P =0.03;7d vs 14d: OR 0.49,95%CI 0.31~0.79,P=0.003), however, there was on statistical significance between 10-day-course and 14–day-course(OR 0.79,95%CI 0.47~1.34,P=0.39). In addition, we have compared the incidence of adverse reactions between the groups of 7–day-course, 10-day-course, and 14–day-course, and it revealed that there were no significant differences between them(7d vs 10d: OR 1.05,95%CI 0.75~1.47,P=0.78;7d vs 14d: OR 0.80,95%CI 0.32~2.00,P=0.63;10d vs 14d: OR 0.82,95%CI 0.45~1.50,P=0.53). Similarly, as for the clinical manifestation remission rates, we also found there were no statistical evidences to indicate which kind of treatment is more effective among the three courses stated above(7d vs 10d: OR 0.79,95%CI 0.31~2.04,P=0.63;7d vs 14d: OR 0.72,,95%CI 0.26~2.00,P=0.53;10d vs 14d: OR 0.92,95%CI 0.32~2.63,P=0.87).Conclusion: When rabeprazole-based triple therapy was selected for the treatment of H.pylori intection, the 10-day-course and 14-day-course treatment were prior to the 7–day-course, however, there was no statistical significance between 10-day-course treatment and 14-day-course treatment. Consequently, the 10-day-course treatment may be a better choice considering about the economic burdern and medication adherence of patients, but more randomized controlled trainls with large sample sizes are warranted in the future.