Antenatal Culture Of Vaginal Microecosys Tem And Group B Streptococcus For Term Pr Emature Rupture Of Membranes And The Cor Relation With Maternal And Neonatal

Objectives:1. To find out the different vaginal microenvironment characteristics of maternal with tPROM and healthy maternal.2.To investigate whether the vaginal Group B Streptococcus infection contributes to term premature rupture of membranes(tPROM).3.the relationship among tPROM,GBS infection and maternal fetal outcomes.Methods: Data were reviewed for women with a singleton pregnancy and PROM who attended The second affiliated hospital of chongqing medical university, between January 2015 and March 2016.First retrospective study The vagina microenvironment characteristics and the obstetric and neonatal outcomes between maternal with PROM and healthy maternal. Diving the tPROM group into four groups according to the vaginal microenvironment and the status of GBS infection,And retrospective study comparing obstetric and neonatal outcomes of the four groups, those with positive GBS vaginal cultures and those without GBS colonization,the normal vaginal microenvironment and the abnormal vagnial microenvironment during pregnancy was conducted.Results: 1.The incidence rate of the vaginal microecology imbalance 、abnormal vaginanl p H(p H>4.5),bacillus acidi lactic odds ratio of maternal with tPROM compared with the healthy maternal(p<0.05),the diference was statistically significant. 2.The major dominant bacteria of maternal with t PROM were Gram-positive cocci(39.18%),while the healthy maternals’ were gram-postive rods(52.70%). 3.The incidence rate of BV, VVC, and BV combined with VVC of maternal with tPROM compared with the healthy maternal(p >0.05),there was no statistically significant difference(p> 0.05),but the rate of GBS infection of maternal with tPROM was higher than healthy maternal,the difference was statistically significant(p< 0.05), and the t PROM group of GBS infection was 16.22%, the control group was 5.41%.4.There were no significant difference on the Apgar1 min score,Apgar5 min score and neonatal abnormal blood p H of the mathernal with tPROM and healthy maternal,while compared with the two groups’ ncidence of pathological jaundice of newborn and puerperal infection,the difference was statistically significant(p<0.05).5.In GBS positive group and negative GBS group, the incidence of the neonatal abnormal blood pH had no significant(p>0.05)),but compared the two groups’ incidence of pathological jaundice of newborn and puerperal infection,the difference was statistically significant(p<0.05).Conclusion: Our study showed there were vaginal microecological imbalances in maternal with tPROM and healthy maternal. A significant association between PROM and imbalances of vaginal microecologica and infection of Group B Streptococcus. and tPROM also can result in adverse obstetrical outcomes,for example the neonatal pathologic jaundice and puerperal infection,especially combine with Group B Streptococcus...