Acute heart failure is an extremely high incidence of disease in people over the age of 65.The administration of loop diuretics to achieve decongestion is the most important therapy for acute heart failure. Unfortunately, impaired response to diuretics is common in these patients and associated with adverse outcomes. Diuretic resistance is thought to result from a complex interplay between cardiac and renal dysfunction. However, our understanding of diuretic response in patients with acute heart failure is still limited and a uniform definition is lacking. Several strategies have been proposed to overcome diuretic resistance. |