| Purpose(1)Analysis of patients with chronic obstructive pulmonary disease with acute aggravating period(acute exacrbations of chronic obstructive pulmonary diseases, AECOPD), stability and healthy controls the breath of nitric oxide(fractional exhaled nitrie oxide, FENO) value; Comparison of COPD patients with acute aggravating period and stable period FENO explore FENO in evaluating the role of hospitalized patients with AECOPD airway inflammation.(2) Analysis of COPD patients with acute aggravating period and stable period FENO value relationship between therapeutic effect and explore FENO value determination of hospitalized patients with COPD acute aggravating period of treatment effect evaluation. Methods(1) In 81 cases of COPD patients with acute aggravating period to the stability of the team, 78 cases of healthy subjects as control group, using breath nitric oxide NIOXMINO measure FENO value; At the same time using the lung function lung function instrument meter(American mecca pulmonary function test system for ELITE DL) determination of its first second forced expiratory volume(forced expiratory volume in one second, FEV1) and forced expiratory volume in the first seconds of the percentage of the expected value(forced expiratory volume in one second/predicated value, FEV1 %).(2) COPD patients with acute aggravating period of comprehensive treatment, the determination of its stabilization and FEV1, FEV1 % FENO values. Results(1) patients with COPD acute aggravating period FENO level plateau above the group;(2) COPD plateau group FENO level higher than the control group;(3) acute aggravating period of COPD group FENO levels higher than the plateau group and the control group(P < 0.05);(4) correlation study found: COPD patients with acute aggravating period group FENO level had no correlation with FEV1, FEV1 %(P > 0.05);Patients with COPD stabilization group FENO level had no correlation with FEV1, FEV1 %(P > 0.05);Acute exacerbation period to stabilization FENO improve value with acute aggravating period to stability improved FEV1 value between positive correlation(P < 0.05), with acute aggravating period to improve stability FEV1 % value also exists between positive correlation(P < 0.05) Conclusion(1) breath nitric oxide determination method is simple, noninvasive, repeatable, and the advantage of quality strictly. COPD patients with acute aggravating period FENO value is higher than the control group, patients with COPD stabilization FENO value; Can prompt FENO reaction COPD airway inflammation in patients with acute aggravating period.(2) of the COPD patients with acute aggravating period and the decline in patients with COPD stabilization its FENO value degree and the correlation between the improvement in lung function after treatment... |
