| Objective To investigate the role of autophagy-related protein Beclin-1and anti-apoptotic protein Bcl-2 in the occurrence and progression of gastric cancer as well as their correlation by detecting their expression in gastric cancer.Methods The expression of Beclin-1 and Bcl-2 in 78 gastric cancer specimens, 30 atypical hyperplasia specimens and 20 chronic superficial gastritis specimens were examined by immunohistochemical staining.Results The positive rate of Beclin-1 in gastric cancer was significantl y lower than those in atypical hyperplasia and chronic superficial gastritis(χ2=9.298,7.437, respectively, P<0.05), while there was no significant difference between atypical hyperplasia and chronic superficial gastritis(P>0.05). The positive rate of Bcl-2 in gastric cancer was significantly higher than those in atypical hyperplasia and chronic superficial gastritis(χ2=11.013, 15.278, respectively, P<0.05), while Bcl-2 expression in atypical hyperplasia showed no significant difference with that in chronic superficial gastritis(P>0.05). The expressions of Beclin-1 and Bcl-2 were significantly correlated with differentiation, depth of invasion and TNM staging(χ2=7.014~16.248, P<0.05), but not correlated with sex, age, tumor size, tumor location and metastasis(P>0.05). The expression of Beclin-1 was negatively correlated with Bcl-2 in gastric cancer(r=-0.396, P<0.01).Conclusion Beclin-1 expression was decreased and Bcl-2 expression was increased in gastric cancer. Both of them were associated with the occurr ence and progression of gastric cancer and negatively correlated with each other. Beclin-1 and Bcl-2 may be used as important markers to predict the biological behavior of gastric cancer. |
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