Clinical Study About The Association Between Metabolic Syndrome And Colorectal Cancer

Objective: Colorectal Cancer(CRC) is one of the most common diseases, and its morbidity and mortality rate show an upward trend year by year. More than one risk factor for CRC incidence, risk factors in addition to age and gender, as well as a family history of colorectal adenomas, inflammatory bowel disease, smoking, excessive alcohol consumption, obesity and diabetes. Metabolic syndrome(MS) is a group of clinical syndrome which takes a group of insulin resistance(IR) as the pathophysiological basis, and build a variety of metabolic disorders appear as the clinical features. It mainly including obesity(especially visceral obesity), hyperglycemia, hypertension, dyslipidemia and Non-alcoholic fatty liver disease(NAFLD). In recent years, the research on the relationship between CRC and MS has been paid more and more attention by scholars. Although some studies have suggested that some factors of MS are related with CRC, but the researches about their correlationship are rare both domestic and international. Therefore, aiming at this point, this paper collected the clinical data of patients with CRC, and analyzed the correlationship between the MS and CRC.Methods: Selecting the Colonoscopy-patients in People’s Hospital of Xinzhou from October 2014 to October 2015 as the research object, strictly screening selected cases recorded in accordance with the patient’s The pathology report and finally divide the group into the CRC group and comparison group. Statistics patient’s blood lipid biochemistry laboratory test provides, blood glucose and in accordance with the patient’s medical history, imaging, endoscopy and other information make statistics about whether the CRC patients have hypertension, metabolic factors related indicators of diabetes, fatty liver diseas or not.By using retrospective analysis of clinical data, collecting the general information of patients and registration data to Excel, then transferred to the statistical software SPSS17.0 for statistical analysis, The first two groups of indicators t test or chi-square test. Comparison between the two groups of gender, age, NAFLD, obesity, whether the differences in the distribution of hypertension, T2 DM and other characteristics; Unconditional Multivariate Logistic regression analysis of gender, age, NAFLD, obesity, hypertension, T2 DM and so on CRC And calculate the odds ratio(OR value) and 95% confidence intervals(95% CI), P <0.05 was considered statistically significant., analyz the correlation between metabolic correlation factors and CRC.Results:1. Collected a total of 799 cases: 344 cases in CRC group,189 males, 155 cases of female; 455 cases in comparison group, which 243 cases were men,212 patients were women.The average age of comparison group is 55.45 ± 8.68, the average age of CRC group is 60.22 ± 13.29, the difference was statistically significant(P <0.05), CRC incidence increases with the trend of age.2. Different parts of groups with metabolic factors related to the number of cases and the percentage of diabetes cases and the proportion of the merged respectively: The complicated with T2 DM and the proportion of the comparison group: 45 cases, 9.9%; the CRC group 117 cases, 34% respectively. The complicated with obesity and the proportion of the comparison group:74 cases, 16.3%; the CRC group 99 cases, 28.8% respectively. With metabolic syndrome and ratio of the number of cases: comparison group:66 cases,14.5%; the CRC group 69 cases, 20.1%. the difference was statistically significant(P <0.05).3. The mean of two groups about blood lipid is: TC: 4.43±1.11(the comparison group),3.95±1.61(CRC group);HDL-c:1.03±0.23(the comparison group),0.76±0.33(CRC group);LDL-c:2.09±0.86(the comparison group),2.37±0.73(CRC group),the difference was statistically significant(P<0.05).TG:1.21±0.28(the comparison group),1.27±0.72(CRC group),the difference was not statistically significant(P>0.05).4. The mean of the comparison group about Systolic blood pressure/diastolic blood pressure is 124.62±18.67/75.73±11.80 mm Hg,The mean of the CRC group about Systolic blood pressure/ diastolic blood pressure is 124.62±18.67/75.73±11.80 mm Hg, the difference was statistically significant(P<0.05).The complicated with hypertension and the proportion of the comparison group: 151 cases,33.2%; the CRC group 126 cases, 36.6%respectively. the difference was not statistically significant(P>0.05).5. After multivariate logistic regression statistical analysis, thinking that the incidence of colorectal cancer are related with diabetes, obesity and Dyslipidemia,there Odds ratio and Confidence Interval are :( 4.213,2.828~6.275;3.378,2.374~4.808;2.290,2.374~4.808;P <0.05), the difference was not statistically significant. Odds ratio and Confidence Interval in the sex, hypertension, non-alcoholic fatty liver disease, HDL-c are:(0.885 0.638~1.227,1.259 0.922~1.721,1.280 0.838~1.957,3.533 0.885~14.10).finding that there is no statistically significant difference in the sex, hypertension, non-alcoholic fatty liver disease, HDL-c, etc,6. The correlation analysis between lymph metastasis and metabolic syndrome in CRC group:there are 78 cases combined metabolic syndrome,and 42 cases had lymph metastasis yet and 36 cases are not. there are 266 cases non-combined metabolic syndrome,and 104 cases had lymph metastasis yet and 162 cases are not. The difference was statistically significant(P <0.05).7. The correlation analysis between liver metastasis and non-alcoholic fatty liver disease in CRC group: there are 87 cases combined metabolic syndrome,and 17 cases had liver metastasis yet and 70 cases are not. there are 257 cases non-combined non-alcoholic fatty liver disease,and 44 cases had liver metastasis yet and 213 cases are not. The difference was statistically significant(P<0.05).Non-alcoholic fatty liver disease and rectum cancer correlation coefficient β=1.442, P<0.05. The difference was statistically significant, suggesting that:Compared with CRC without NAFLD,CRC with NAFLD occurs in the rectum area more often, which have lower rate on the liver metastases.Conclusion:1.There is a certain correlation between CRC and some component of MS, such as Dyslipidemia,T2 DM,and obesity, and which are all independent risk factors for the occurrence of CRC.2.CRC patients with normal liver have higher liver metastases risk than those with NAFLD;The patients with colon cancer have higher liver metastases risk than those with rectum cancer.