| Objective:Study of Hashimoto’s thyroiditis in the pathogenesis of system lupus erythematosus (SLE) and to investigate this two diseases with their clinical and laboratory characteristics and clinical diagnosis and treatment of these two disease simultaneously.Method:A retrospective study was conducted at the second and first affiliated hospitals of Kunming Medical University,through retrospective form records and telephone pays a return visit. A total of 1029 SLE cases were selected, group ’A’:80 cases of SLE with thyroid Thyroglobulin(TGAb), thyroid peroxidase antibody thyroid peroxidase antibodies, (TPOAb) abnormal but did not reach the diagnostic standard of Hashimoto’s thyroiditis(By the subsequent hospital information or telephone pays a return visit, the 80 cases of patients with SLE TgAb, TPOAb became negative through six months treatment); group’B’:29 cases of SLE accompanying with HT(By the same method, the 29 cases of patients with SLE TgAb, TPOAb through six months treatment still are positive and thyroid ultrasound); group’C’:920 cases SLE had normal TGAb, TPOAb, from the same time of hospital ization, gender 1:l,and 109 cases belonged to a control group. Of antinuclear antibody spectrum, Urinary system, nervous system, blood system, liver, renal function, disease activity score index characteristics.Count data with c2 inspection.measurement data using analysis of variance and rank sum test,screening statistically significant Single factor, then using the binary classification Logistic regression analysis found that independent risk factor for SLE with HT.Result:In total 1029 SLE patients,29 patients with Hashimoto’s thyroiditis, the total incidence rate was 2.8%. Three groups of mitochondria m2[18.7%,24.1% and 6.08% respectively,(P<0.05)], oral ulcer [8.75%,27.5% and 8.69% respectively,(P<0.05)], red blood cells decrement rate [21.3%,17.2% and 33.9% respectively,(P<0.05)] hemoglobin decrement rate[25%,38% and 43.4% respectively,(P<0.05)], TGAb level [4.01(3.10-5.50),6.10(3.40-103.54) and 0.00 respectively, P<0.05],TMAb level (later found with TPOAb is the same substance,TPOAb) [3.75(2.70-5.50),6.00(3.30-126.50) and 0.00 respectively, P<0.05], T4 level [0.00,0.00(0.00-5.20) and 0.00 respectively, P<0.05], TSH level[0.00,0.00(0.00-9.80) and 0.00 respectively,P<0.05], FT3 level [0.00,0.00(0.00-1.46) and 0.00 respectively,P<0.05], Although having statistically meaningful, FT3 was in the normal range, no clinical meaningless.FT4 level [0.00 (0.00-0.75),0.00(0.00-1.46) and 0.00 respectively,P<0.05], pus cells in urine [1.70± 0.05,0.26±0.14 and 0.57±0.12 respectively, P<0.05], globulin level[30.27±5.91, 34.23±10.67 and 32.86±7.85 respectively, P<0.05], the high density lipoprotein [1.74 ±0.72,2.36±0.96 and 1.73±0.07 respectively, P<0.05] the binary classification Logist-ic regression analysis SSA, SSB, RNP antibodies, red blood cells, hemoglobin were statistically different (P<0.05), which SSB positive rate of 0R=6.43, Hemoglobin decrement rate. OR=0.45.Conclusion:1.SLE with Hashimoto’s thyroiditis disease occurrence is higher in old age with the prevalence rate of 2.8%.2.The hematological involvement is minimal in SLE with Hashimoto’s thyroiditis. Among which SSA antibodies expression is due to protective factors. However, RNP and SSB antibodies are risk factors.3.There is no relation between Hashimoto’s thyroiditis in SLE patient prevalence with SLE disease activity. |
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