| Objective:We make this clinical research to evaluate the therapeutic effect and safety of antiviral Chinese medicine preparation through to antiviral Chinese medicine preparation contrast Pidotimod (Brand name:FuLu decoction)in the treatment of damp-heat syndrome in young women with cervical hrHPV (high-risk Human Papilloma Virus, hrHPV) infection.Method:A total of 90 women at the age of 25 to 35 who met the inclusion criteria and visited the Gynecological Clinic of Changzhou TCM Hospital from June 2015 to December 2015 were randomly divided into 2 groups. The control group took Pidotimod and the treatment group was treated with antiviral Chinese medicine preparation.30 cases in each group, treatment according to the research plan. Comparison the data of before and after treatment and the data between the two groups to evaluate the therapeutic effect of antiviral Chinese medicine preparation. And evaluate safety of antiviral Chinese medicine preparation by clinical biochemical indexes.Results:1.Comparison of clinical symptom scores in Chinese medicine(1)Comparison of symptom scores of three groups before and after treatment:the treatment group all the TCM clinical symptoms of Damp-heat syndrome combined hrHPV patients were improved significantly after treatment. After treatment of gynecological and systemic symptoms were no nor only slight improvement in the control group.(2) Comparison of total score of clinical symptom in Chinese medicine:In the treatment group, the total score of traditional Chinese medicine symptoms in the treatment before and after the comparison has significant statistical significance, control group and before and after the treatment of clinical symptoms integral significance was not obvious.2. Comparison of hrHPV viral load volume and negative rate(1)The treatment group and the control group the viral load of before and after the treatment was significantly statistically significant (p=0.01, p<0.05). And the treatment group reduced hrHPV viral load is better than the control group.(2)The control group after treatment for 3 months,6 months overcast rate was 20%, 33.3%, the treatment group after treatment for 3 months,6 months of overcast rate was 36.7%,63.3%. Comparison of two groups of overcast rate statistically significant (p< 0.05).3. Before and after treatment the comparison of total effective:the control group cure rate for 10%, total effective rate 63.3%, treatment group cure rate for 26.7%,the total effective rate 86.7%. Comparison of two groups of total effective rate was statistically significant (p< 0.05).4. Safety observation:the treatment group after treatment to check liver and kidney function, blood in urine routine, blood coagulation function, blood biochemical indicators such as not seen obvious abnormity, during treatment does not appear related to medication obvious adverse reactions.Conclusion:Antiviral Chinese medicine preparation and pidotimod can obviously shorten the young women cervical hrHPV infections self-healing deadline, can remove the HPV virus, viral load reduction, improve the clinical symptoms of patients. Early intervention treatment of Chinese and Western Medicine has obvious clinical significance, and Chinese medicine treatment effect is superior to western medicine. Traditional Chinese medicine (TCM) economical, safe non-toxic side effects. |
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