| [Objective] Observe the effect of acupoint application intervention efficacy and side effects of azithromycin in children gastrointestinal reactions from clinical research of the system, To provide evidence for clinical intervention of gastrointestinal tract reaction caused by azithromycin in Chinese Medicine.[Methods] 208 cases were randomly divided into experimental group and control group in this study,104 cases in each group, the two groups were carried out in the general care (including drip rate, concentration control, diet care, emotional care), the implementation of the placebo control group acupoint application, the implementation of Chinese medicine acupoint application test group, were once a day for 5 days sticking. Children were observed incidence of gastrointestinal side effects, the degree of occurrence, the occurrence of form, time of administration, compliance and other indicators to evaluate the intervention effect.[Results] Chinese medicine acupoint application Intervention for Children intravenous azithromycin-induced gastrointestinal reactions observations:①Children intravenous azithromycin-induced gastrointestinal reactions gender groups, the difference was not statistically significant (P> 0.05); the incidence of gastrointestinal reactions is closely related to the age, the lower the age, the incidence of gastrointestinal reactions the higher, 3 to 6 age group of children with gastrointestinal reactions highest rate of 36.30%,7 to 12 years old 19.15%,13 to 14 years is 13.33%.② Two groups of children the incidence of gastrointestinal reactions:the experimental group no response 95 cases, nine cases have reactions, The overall incidence rate was 8.65%; control group,62 cases of non-response, a response in 42 cases, gastrointestinal Road overall incidence of adverse reactions 40.38%, experimental group gastrointestinal adverse reactions overall lower incidence in the control group, the difference was statistically significant (x2=28.289, P<0.05).③ Two groups of children gastrointestinal reactions comparative degree:the degree of reaction test group of children with gastrointestinal lighter than infants in the control group, the difference was statistically significant (Z=-5.295, P<0.05).④ About two gastrointestinal reactions occur in the form of comparison:7 cases of abdominal pain,3 cases of nausea and vomiting two cases, one case of diarrhea in the experimental group; compare to 28 cases of abdominal pain,14 cases of nausea and vomiting in 9 cases,5 cases of diarrhea in the control group; test group patients child abdominal pain, nausea, vomiting rate than the control group, the difference was statistically significant (P<0.05); the incidence of diarrhea, the difference was not statistically significant (X2= 2.74, P> 0.05).⑤ The average time observed two groups of children found that infusion of azithromycin: Azithromycin experimental groups were given the average time for the 64 cases in 1 to 3 hours, 24 cases of 3 to 4 hours, more than 4 hours 16 cases; the control group intravenous azithromycin average time of 31 cases within 1 to 3 hours,39 cases in 3 to 4 hours,34 cases more than four hours, the test group average azithromycin infusion time is shorter than the control group, the difference was statistically significant (Z=-4.494, P< 0.05).⑥ Comparison of two groups of children with treatment compliance:fully compliant test group, 95 cases fully compliant rate of 91.35% in the control group,62 cases fully compliant, fully compliant rate was 59.62% in the control group,40 cases of partial compliance, partial compliance rate accounted for 38.46%, and the control group 2 patients noncompliance. Compliance was higher on compliance, the experimental group, the difference was statistically significant (Z=-5.103, P<0.05).[Conclusions] In conventional interventions based on the use of traditional Chinese medicine acupoint application that could reduce the incidence of azithromycin-induced gastrointestinal reactions, reducing the extent of gastrointestinal reactions, can effectively alleviate gastrointestinal side effects caused by children intravenous azithromycin, azithromycin increases children tolerance, shorter infusion time of children and improve the potency of antibiotics, while improving children’s treatment compliance and comfort. |
