Efficacy Of Simethicone In Improving Visibility During Upper Endoscopy

Objective:Our aim was to assess the. efficacy of simethicone in improving endoscopic visibility and determine the contributions of dose, volume and premedication time.Methods:The study was conducted at Second Affiliated Hospital, Zhejiang University, between December 2015 and March 2016. A total of 403 patients were prospectively treated in three groups:group A:15 mL simethicone suspension in 15 mL water; group B:15 mL simethicone suspension in 50 mL water; group C:control group, 65 mL water. Two liquid premedication groups were further divided into two subgroups on the basis of premedication time by an ad-hoc sampling design method (10-20 min, 30-40 min). We assess the mucosa visibility at five sites of upper gastrointestinal tract, examination time and lesion detection rate. The sum of score was considered as total mucosal visibility score(TMVS).Results:In endoscopy, the means of the TMVS among groups A, B, C were 5.83-1.01,5.85-1.27 and 7.57±1.69, the mucosa visibility score of group A and B were significantly lower than those of group C (P<0.05), in the esophagus, gastric fundus and upper body of stomach, the mucosa visibility score of group A and B were significantly lower than those of group C (P<0.05). The TMVS for group A and B were no significant difference (P>0.05). The TMVS for groups Al (5.94±1.05) was not significantly lower than for group A2 (5.67±0.92).There was no significant difference in the TMVS between group B1 (5.78±1.12) and B2 (5.92±1.43). There were no significant differences between the three groups with respect to lesion detection rate, only the eminence lesions (<5mm) detection rate of group B (28/134) preceded than group C (14/136)Conclusions:premedication using simethicone improves endoscopic visibility and lesion detection rate.