The Clinical Effect Of S-1 Single Agent Resection Of Chemotherapy On Patients Who Accepted Radical Cholangiocarcinoma

Objective:In order to explore the clinical effects of S-1 single agent chemotherapy for patients who underwent radical resection of cholangiocarcinoma.Methods:The clinical study data of 51 patients accepting radical resection of cholangiocarcinoma who are admitted to the second Affiliated hospital of Zhejiang university from november 2011 to december 2013 were retrospectively analysed. After accepting radical resection of cholangiocarcinoma,25 patients receiving non-special treatment and 26 patients receiving S-1 single agent chemotherapy for 6-8 courses of treatment were divided into the non-chemotherapy group and chemotherapy group, respectively. S-1 were taken orally twice per day. forty mg/once of S-1 was applied to patients with the body surface area(BSA)<1.25 m2,50 mg/once of S-1 was applied to patients with the BSA≥1.25 m2 and<1.5 m2,60 mg/once of S-1 was applied to patients with BSA≥1.5 m2. The 14 days usage and 7 days withdrawal of S-1 were used as one course of treatment. All the patients were followed up by outpatient examination and telephone interview till December 1,2014. Count data were analysed using the chi-spuare test, measurement data with normal distuibution were presented as x ± S and analysed using the t test, survival curve was drawn by the Kaplan-Meier method, and survival analysis was done using the Log-rank test.Results:Twenty-six patients in the chemotherapy group finished the given courses of chemotherapy without appearance of chemotherapy-related death, and 14 patients appeared chemotherapy adverse reactions with remission after discontinuation of S-1.All the 51 patients were followed up for 5-37 months with a median follow-up time 19 months.The median overall survival time,1-,3-year overall survival rates, tumor-free median survival time and 1-,3-year tumor free survival rates were 22 months (range,18-27 months),72.3%,42.9%,21 months (range,16-26 months),60.0%,55.0% in the non-chemotherapy group and 32 months (range,29-35 months),84.6%,44.4%, 26months (rangs,21-31 months),76.9%,61.9% in the chemotherapy group; respectively. There was a significant difference in the overall survival between the 2 groups (x2=6.032, P< 0.05). However, there was no significant difference in the tumor-free survival between the 2 groups (x2=0.498, P>0.05).Conclusions:S-1 single agent chemotherapy can bring significant survival benefit to patients who accepted radical resection of cholangiocarcinoma. However, S-1 single agent chemotherapy was no clinical significance in terms of inhibiting tumor recurrence after radical resection.