Metabolic Complications After Liver Transplantation:A Retrospective Study

Backgrond/aims:Liver transplantation is the best therapy of choice for patients with acute liver failure and end-stage liver diseases. With the long-term survival of liver-transplant recipients and usage of marginal liver in liver transplantation such as Donation after Cardiac Death, long-term complications for instance, recurrence of tumor and hepatitis, biliary complication, chronic graft dysfunction and metabolic disorders have become more and more important for long-term surviving of the receptors. post-transplant metabolic syndrome, diabetes, dyslipidemia, hypertension, cardiovascular diseases, HCV recurrence and infectious complications are closely linked with metabolic complications, is the impact of liver transplantation in patients with long-term prognosis of the main reason.In recent years more and more scholars awareness the importance of further study.Methods:Cases of The 1st Affiliated Hospital of Zhejiang University during 2010.01.01 to 2015.02.28,245 recipients undergoing cadaveric related liver transplantation. Analysis morbidity an risk factors of post-transplant metabolic complications, such as hyperglycaemia, hypertriglyceridemia, Low levels of HDL and hyperuricemia, and Impact on the long-term outcomesResults and Conclusion:1. Metabolic complications are common complications after liver transplantation.1 year after liver transplantation,27.8% of patients were the presence of high blood sugar, where the incidence of new-onset diabetes was 10%,17.9% of patients had hypertriglyceridemia,54.3% patients with low HDL-c hyperlipidemia,42.3% of patients with hyperuricemia.2. Prolonged warm ischemia can increase the risk of postoperative hyperglycemia, with warm ischemia time greater than 30 min, glucose metabolism was significantly increased;3. Preoperative high TG hyperlipidemia were independent risk factors for post-LT high TG hyperlipidemia, preoperative primary disease is cirrhosis or liver failure of HBV in patients prone to high TG hyperlipidemia;4. The prolonged warm ischemia can increase the risk of postoperative hyperuricemia;5. In the average 2-year follow-up after liver transplantation hyperglycaemia, hypertriglyceridemia, Low levels of HDL and hyperuricemia did not significantly affect survival rates.