| Objective:This study is to investigate the laws of the changes of Qi deficiency of different viscera before and after DP and GP many courses of chemotherapy of the middle and terminal non-smoll cell lung cancer, so as to provide the basis theory of different chemotherapy regimens combined with traditional Chinese medicine of non-small cell lung cancer and the theory of preventive treatment.Methods:Used the method of epidemiological studies, collected the Ⅲ, Ⅳ Non-small cell lung cancer patients with chemotherapy treatment in the cancer center of our hospital between 2015.8-2016.1. Bring into the observation object according to the inclusion criteria, then observed and collected Qi deficiency syndrome before and after chemotherapy of them. According to diagnostic criteria of qi deficiency in Diagnostics of TCM and the main symptoms of qi deficiency of non-small cell lung cancer in clinical practice, this topic formulated the symptom classifying quantization form and the diagnostic criteria of Lung Qi deficiency, Spleen Qi deficiency, heart qi deficiency, kidney qi deficiency and blood-insufficiency. Based on relevant diagnostic criteria, then graded and determined the syndrome of TCM of observation object according to their tongue coating and pulse condition. And recorded quantitative value of the White blood cells, red blood cells, neutrophils, hemoglobin and platelets of the patients. Then used statistical methods to analyze the data, then summarized and concluded the laws of the changes of Qi deficiency before and after DP and GP many courses of chemotherapy of the Non-smoll-Cell lung cancer.All the data were processed by IBM. SPSS. Statistics 19. Used matching t test, to analyze the integral changes of qi deficiency before and after different courses of chemotherapy. Used chi-square test, to analyze the difference of the type of syndrome before and after different courses of chemotherapy. Used rank sum test, to analyze the differences of the integral changes before and after the patient treatment between different courses of chemotherapy. Used the correlation analysis, to compare all the integral of the qi and blood deficiency to the quantitative value of WBC, RBC, PLT, NEU, HGB. There are statistically significant differences based on P< 0.05.Results:1. The comparison before and after every course of chemotherapy of DP1.1 The simple list of the Pof the the integral of aggregate qi deficiency, lung qi deficiency, spleen qi deficiency, heart qi deficiency, kidney qi deficiency and blood-insufficiency before and after 4 courses of chemotherapy of DP:1.2 The simple list of the Pof the the integral of aggregate qi deficiency, lung qi deficiency, spleen qi deficiency, heart qi deficiency, kidney qi deficiency and blood-insufficiency before and after 4 courses of chemotherapy of DP:1.3 The number of spleen qi deficiency syndrome type after every chemotherapy was significantly higher than before(P<0.05).Other syndrome types had no statistical significance before and after chemotherapy.1.4 There was a negative correlation between the the integral of lung qi deficiency and the quantitative value of RBC, HGB and PLT before and after chemotherapy (r=-0.846, P<0.01; r=-0.765, P<0.05; r=-0.882, P<0.01). There was a negative correlation between the the integral of spleen qi deficiency and the quantitative value of PLT before and after chemotherapy (r=-0.886, P<0.01). There was a negative correlation between the the integral of heart qi deficiency and the quantitative value of RBC and PLT before and after chemotherapy (r=-0.728, P<0.05; r=-0.769, P <0.05). There was a negative correlation between the the integral of kidney qi deficiency and the quantitative value of RBC and PLT before and after chemotherapy (r=-0.718, P<0.05; r=-0.733, P<0.05). There was a negative correlation between the the integral of blood deficiency and the quantitative value of PLT before and after chemotherapy (r=-0.790, P<0.05).The rest of the syndrome type and the quantitative value of the blood cell had no significant correlation.2. The comparison before and after every course of chemotherapy of GP2.1 The simple list of the Pof the the integral of aggregate qi deficiency, lung qi deficiency, spleen qi deficiency, heart qi deficiency, kidney qi deficiency and blood-insufficiency before and after 3 courses of chemotherapy of GP:2.2 The simple list of the Pof the the integral of aggregate qi deficiency, lung qi deficiency, spleen qi deficiency, heart qi deficiency, kidney qi deficiency and blood-insufficiency before and after 3 courses of chemotherapy of GP:2.3 The number of spleen qi deficiency syndrome type after every chemotherapy was significantly higher than before (P<0.05). The number of heart qi deficiency syndrome type after the three cycles of chemotherapy was significantly higher than before (P<0.05). Other syndrome types had no statistical significance before and after chemotherapy.2.4 There was a negative correlation between the the integral of lung qi deficiency and the quantitative value of WBC, RBC and HGB before and after chemotherapy (r=-0.902, P<0.05; r=-0.846, P<0.05; r=-0.882, P<0.05). There was a negative correlation between the the integral of spleen qi deficiency and the quantitative value of WBC, NEU, RBC and HGB before and after chemotherapy (r=-0.942, P<0.01; r=-0.831, P<0.05; r=-0.814, P<0.05; r=-0.851, P<0.05). There was a negative correlation between the the integral of kidney qi deficiency and the quantitative value of RBC and HGB before and after chemotherapy (r=-0.943, P<0.01; r=-0.919, P<0.01). The rest of the syndrome type with the quantitative value of the blood cell had no significant correlation.Conclusion:1. The patients’ symptom of spleen qi deficiency was worse after the first cycle of chemotherapy. And it gradually worsen with the increase of the cycle of chemotherapy. The incidence of spleen qi deficiency was increased after chemotherapy than before. And it gradually increased with the increase of the cycle of chemotherapy. The heart qi deficiency, kidney qi deficiency and blood deficiency had no significant correlation before and after chemotherapy. This prompt that the treatment of benefit the lung and spleen qi should be emphasized before and after chemotherapy. In the modern medicine, the nutritional support treatment should be enhanced, so as to make the patients more resistant to chemotherapy. It should be more strengthened to benefit the lung and spleen qi after many courses of chemotherapy.2. There was a correlation between the degree of weakness of qi and blood and the decline of the blood cell. It can provide some references to treat the chemotherapy patients with integrated Chinese and western medicine.3. The above results proved that chemotherapy damaged the heathy zang qi, to provide data support for the theory of "poison cures" from Chinese medicine. But the present study lack case load, it is necessary to expand the sample size to get more scientific and real results. |
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