| Objective1. To investigate the brain functional changes of patients with Type 2 diabetic retinopathy by regional homogeneity of the resting-state functional Brain magnetic resonance imaging2. To analysis the brain functional changes of patients with Type 2 diabetic retinopathy by Functional connectivity of Based on the posterior cingulate for seed point, and To analysis correlation with the clinical risk factors、neurocognitive scale scores and functional connectivity in Type 2 diabetic retinopathy.Materials and methodsTrio 3.0T Siemens magnetic resonance scanner was used in this study, This experiment divides into three groups: Diabetes retina pathological change group(diabetic retinopathy DR), altogether 15 examples, male 7 examples, female 8 examples; Diabetes non-retina pathological change group(non-diabetic retinopathy NDR), altogether 17 examples, male 9 examples, female 8 examples, normal control group(normal control NC) altogether 21 examples, male 9 examples, female 12 examples. Biochemical tests were performed in all patients. including blood pressure, fasting blood glucose, glycosylated hemoglobin, cholesterol, triglyceride group, low density lipoprotein, high density lipoprotein and fasting insulin resistance. And all subjects of cognitive neuropsychological tests, including MMSE and Mo CA、Trail-Making Test Part A and picture recall of the Wechsler Memory Scale. Statistical analysis based on MATLAB 7.0 platform using resting state functional magnetic resonance imaging data analysis toolkit of three groups of subjects data of Re Ho analysis processing and extract three groups of Re Ho values with SPSS 19.0 software package are pairwise independent sample t test, Variance analysis was performed on clinical biochemical indexes and neuropsychological cognitive scores between the three groups.Results1. General clinical treatment results:(1)gender, age, diastolic blood pressure and educational level in the three groups showed no differences between the three groups, but the systolic blood pressure showed significantly different.(2)biochemical examination of fasting blood glucose, glycosylated hemoglobin and fasting insulin resistance in among the three groups showed significant difference; cholesterol, glycerin three groups, low and high density lipoprotein howed no significant difference. The MMSE, Mo CA, Trail-Making Test Part A and picture recall of the Wechsler Memory Scale showed significant difference in three groups.2.(1)Compared with normal group, NDR group Re Ho values decreased brain regions including anterior cingulate gyrus, right superior frontal gyrus and right middle frontal gyrus, increased brain regions frontal gyrus, rectus gyrus and left cuneus, increased brain regions bilateral cerebellum and left precuneus.(3)Compared with NDR group, DR group Re Ho values reduce brain regions including the right middle frontal gyrus, right inferior frontal gyrus, right precentral, calcarine gyrus, left cuneus, increased brain regions including the bilateral cerebellum and bilateral precuneus. including the parietal lobe, right middle frontal gyrus, Right precentral gyrus and left precuneus.(2)Compared with the normal group, DR group Re Ho values decreased brain regions including anterior cingulate gyrus,calcarine gyrus, right superior frontal gyrus, right middle frontal gyrus, right inferior frontal gyrus, left superior3. Based on bilateral posterior cingulate gyrus for the seed region, the use of voxel based FC method is derived.(1)NDR group compared with the normal control group, bilateral posterior cingulate gyrus and any other brain areas did not showed significantly increase and decrease the brain area.(2)DR group compared with normal controls group, Bilateral posterior cingulate cortex function connected to the main performance of the anterior cingulate gyrus, left superior frontal gyrus, the left middle frontal gyrus, left inferior frontal gyrus, right superior frontal gyrus, right frontal back and rectus gyrus with decreased functional connectivity, bilateral cerebel ar functional connectivity showed increased.(3)DR group compared with NDR group, Bilateral posterior cingulate cortex function connecting the main cingulate gyrus, left superior frontal gyrus, the left middle frontal gyrus, right superior frontal gyrus and rectus gyrus function reduced in the functional connectivity and no brain regions showed significant increase in function connection.Conclusion1. Type 2 diabetic retinopathy and diabetes with non retinopathy compared with normal control group resting state functional study showed brain functional change, type 2 diabetes with non retinopathy mainly concentrated on the default network area, and type 2 diabetic retinopathy in addition to the default network area change, visual network area also changed.2. Based on bilateral posterior cingulate gyrus for the seed region and any other brain regions showed no significant functional connectivity abnormalities in type 2 NDR and normal control group, explained The brain function of patients with type 2 NDR had no obvious change, While type 2 DR compared with normal control group and NDR group. The posterior cingulate occurred abnormal functional connectivity with multiple brain regions, suggesting Patients with type 2 DR had more brain function damage.3. After type 2 DR cingulate for seed points and function connection strength and MMSE in multiple regions, Mo CA there is negative correlation, is positively correlated with blood glucose. |
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