Study On Regional Homogeneity And Functional Connectivity Of Resting Brain Functional Magnetic Resonance In Early Blind Adolescents

Objective: To explore the changes of regional homogeneity and functional connectivity of early blind adolescents using resting brain functional magnetic resonance.Basedon functional imaging,to discuss the neurological and physiological mechanisms.Methods: twenty-twoearly blind patients(EB group)and eighteen age-and gender-matched sighted healthy control(HC group)were recruited in this study.They were performed resting-state functional magnetic resonance imaging(rs-f MRI),and regional homogeneity(Re Ho)analysis was used to identify the brain areas with significant differences between two groups.The brain regions with statistically significant differences between two groups of Re Ho values was used as the ROI to take functional connectivity(FC)analysis.And the correlation between the Re Ho value,FC value of significantly brain regions in EB patients and duration of blindness was investigated respectively.Results: Compared with the matched group,Re Ho values decreased markedly in early blind patients in the left calcarine cortices,and functional connectivity significantly decreased in the left cuneus cortex,left lingual cortex,left cerebellum Anterior lobe in EB group.There were no significant correlations between the duration of blindness and the Re Ho values in the left calcarine cortices,and the FC values in the left cuneus cortex,left lingual cortex,left cerebellum Anterior lobe.Conclusion: 1.In the resting state,compared with the control group,the early blind group had a brain area with reduced Re Ho value on the left calcarine cortices;suggesting that the brain activity of the brain area is reduced,there may be functional abnormalities or damage.2.Compared with the control group,the early-blind group has functionally connected brain regions with reduced FC values: left cuneus cortex,left lingual cortex,left cerebellum Anterior lobe;suggesting that early visual deprivation may cause multiple high-level visual cortical neuronal abnormalities.This phenomenon helps to understand the changes in brain function in patients after early visual deprivation.3.There is no significant correlation between the left calcarine cortices Re Ho value,the left cuneus cortex,the left lingual cortex,the left cerebellum Anterior lobe FC value and the duration of blindness.It is possible that local consistency and functional connectivity are related to other clinical features.