| Purpose:This study was to observe the parameters of Shenlou Ningxin free decoction degree of improvement of stable angina with the syndrome of phlegm and blood stasis,ECG changes, and changes in lipid profiles in patients with clinical symptoms and other aspects of the role of coronary heart disease, were in progress of Piper Ningxin Free correlation analysis and safety evaluation to assess the parameters of Shenlou Ningxin free decoction for the treatment of patients with stable angina clinical efficacy.Method:In this study, a randomized controlled clinical study, patients were from the provinces of Heilongjiang Academy of Traditional Chinese Medicine specialist outpatient, inpatient hospital medicine.Between the ages of 45-75 years, the phlegm closed resistance, blood stasis type of stable angina pectoris were divided into treatment group and control group of 30 patients, the treatment group with the participation of Piper on the basis of conventional western medicine Ning Xin Free decoction, control group was given western medicine Danlou tablet, with a course of14 days before and after treatment was observed syndromes, angina extent, ECG,blood lipids related changes, comprehensive evaluation parameter of Piper Ningxin Free decoction treating coronary heart disease clinical efficacy.Result:1.After 14 days of treatment, both groups of angina symptoms were improved, the difference was statistically significant(P <0.05); the treatment group, the total effective rate was 93.3%, while the control group, the total effective rate was 80.0%,between the two groups, the difference was statistically significant(P <0. 05), the treatment group showed improvement in angina total efficiency better than the control group.2.After 14 days of treatment, both groups of Chinese symptoms were improved, the difference was statistically significant(P <0.05); the treatment group, the total effective rate was 96.7%, while the control group, the total effective rate was86.7%,between the two groups, the difference was statistically significant(P <0. 05),the treatment group showed improvement in Chinese symptoms total efficiency better than the control group.3.Chinese medicine symptom score compared to after treatment in both groups improved to some extent; between the two groups, the difference was statistically significant(P <0.05), indicating that the treatment group was better than the control group in improving TCM symptoms.4.ECG prompt, treatment group improved ischemic electrocardiographic performance,the total effective rate was 86.7%, while the control group, the total effective rate was60.0%, the two groups of patients with ischemic electrocardiographic manifestations were improved to some extent. ECG efficacy were compared by chi-square test, P<0.05, the difference was significant, indicating that the treatment group was better than the control group in terms of improving the ischemic electrocardiographic performance.5.two groups of patients before and after treatment serum lipids HDL, LDL, CHO,TG values were analyzed before and after treatment were compared by t test, the difference was statistically significant(P <0.05); after treatment between the two groups, the difference was not statistically significant(P> 0.05), two lipid changesd approaching.6.Two groups of patients before and after treatment of hypersensitive C reactive protein values were analyzed before and after treatment were compared by t test, the difference was statistically significant(P <0.05), indicating the treatment and control groups reactive protein in patients with hypersensitivity to reduce C terms were valid;between the treatment groups, the difference was statistically significant(P <0.05),the effect of the treatment group was better than the control group.7.The difference was statistically significant between the two groups(P <0.05), the total effective rate of the glonoine reduction was 94.7% in treatment group but 61.1%in the control group.8.There was no obvious change of the dectetion of the blood, urine routine, and liver and kidney function in both two groups, as well as no serious adverse reaction, and there was no statistical signification in and between two groups(P>0.05), thus both two groups were provided with good safety.In conclusion:Shenlou Ningxin free decoction of phlegm closed resistance, blood stasis effect the exact type of stable coronary heart disease, is able to improve the clinical symptoms, relieve angina better than western medicine Danlou tablet. To improve chest tightness, shortness of breath, symptoms of heart palpitations, Shenpi, fatigue,dark purple complexion, spontaneous perspiration better than western medicine Danlou tablet group. Free use of Shenlou Ningxin free decoction treatment of stable angina pectoris with the syndrome of phlegm and blood stasis,is safe and have a significant effect in many prospects.It deserves the clinical expansion. |
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