| 【Objective】The documents about the correlations of fecal calprotectin(FC) with Simple endoscopic score for Crohn’s disease(SESCD), serological indicators, CDAI, as well as the capacity of fecal calprotectin evaluate the situation of Crohn’s disease were limited in the domestic. The aim of this study is to evaluate the correlations between the fecal calprotectin and Simple endoscopic score for Crohn’s disease, serological indicators and CDAI, and determine the ability of fecal calprotectin evaluate the situation of Crohn’s disease.【Methods】Patients diagnosed Crohn’S disease,with complete medical history data, who were admitted to our hospital, from November 2013 to January 2016 were collected. Record the basic situation, medical history, fecal calprotectin concentration, serological indicators, colonoscopy examination and imaging information. A total of 20 Patients were included. The date was input SPSS17.0 for Windows for statistical analysis.【Results】1. The abilities of FC, CDAI, CRP, WBC, ESR, PLT, HB, ALB differentiate between inactive CD and active CD: the patients were divided into 2 groups according to the SESCD. The active group(SESCD>3)15 cases(75%), the inactive group(SESCD≤3)5 cases(25%). The median(IQR) of FC, CDAI, CRP, WBC, ESR, PLT in active group were 1800(IQR1000-1800) ug/g, 213(100-350), 25(11-73.4) mg/L, 6.4(5.1-7.5) ×109/L, 25(12-41) mm/H, 315(235-370)×109/L respectively, which were significantly higher than those in inactive group: 105(62-221)ug/g, 71.1(60.5-104.1), 6.8(3.65-7.2)mg/L, 4.6(3.3-6)×109/L, 6(5-8.5)mm/H, 273(167-312.5)×109/L. In addition to PLT, the differences were statistically significant(P<0.05). Although the median of HB, ALB in IV active group lowered than the inactive group, but the differences were not statistically significant(P>0.05).2. The abilities of FC, CDAI, CRP, WBC, ESR, PLT, HB, ALB discriminated inactive, mild, middle-sever active disease: the patients were divided into 3 groups: inactive group(SESCD≤3)5 cases(25%), mild active group(4-10)4 cases(20%), middle-sever active group(≥11)11 cases(55%). FC was the only indicator that have statistical differences between inactive endoscopic disease and mild activity(P<0.017), mild activity and middle-sever activity(P<0.017).3. spearman’s rank correlation analysis: the spearman’s rank correlation coefficients between SESCD and FC, CDAI, CRP, WBC, ESR, ALB were 0.934, 0.42, 0.49, 0.529, 0.725,-0.454, respectively. And all have statistical significance(P<0.05). FC correlated closest with SESCD, followed by ESR, WBC, CRP, ALB, CDAI. However SESCD failed to correlated with PLT and HB(P>0.05). The spearman’s rank correlation coefficients between FC and CDAI, CRP, WBC, ESR, ALB were 0.466, 0.583, 0.574, 0.678,-0.394, respectively. All have statistical significance(P<0.05). FC correlated closest with ESR, followed by CRP, WBC, CDAI、ALB, but FC failed to correlated with PLT, HB(P>0.05).4. The accuracies of FC, ESR, CRP, CDAI, WBC,ALB detected endoscopic activity: ROC curve analysis revealed that the AUC of FC, ESR, CRP, CDAI, WBC and ALB were 1, 0.940, 0.913, 0.867, 0.833,0.84, respectively. All have statistically significant compared with 0.5(P<0.05). The optical cutoff levels of FC, ESR, CRP, CDAI, WBC, ALB for the detection of endoscopic activity were 221ug/g, 11mm/H, 9.15mg/L, 141, 5.05×109/L,40.95g/L, respectively.【Conclusion】1. All of FC, CDAI, CRP, WBC, ESR have abilities for the detection of endoscopic active inflammation. The best accuracy was FC, followed by ESR, CRP, CDAI, WBC. The optical cutoff levels of FC, ESR, CRP, CDAI, WBC for the detection of endoscopic activity were 221ug/g, 11mm/H, 9.15mg/L, 141, 5.05×109/L, respectively.2.Among FC, CDAI, CRP, WBC and ESR, only FC has statistical differences between inactive endoscopic disease and mild activity, mild activity and middle-sever activity.3. FC correlated closest with SESCD, followed by ESR, WBC, CRP, ALB, CDAI. |
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