Investigations On The Efficacy Of Buyanghuanwu Decoction In Functional Recovery Of Spinal Cord Following CSM

Objective:To investigations the efficacy of Buyanghuanwu Decoction in functional recovery of spinal cord following CSM, and to explore the mechanism underlying.Methods:60 cases of CSM admitted by were chosen Fuzhou General Hospital of Nanjing Military Region, department of Orthopedics from November 2014 to December 2015, which has been successfully treated by anterior surgical decompression of the spinal cord. According to the visiting sequence, the natients randomly divided into experimental group and control group,30 cases in each group. All patients were treated according to after conventional rehabilitation therapy, experimental group on the basis of after conventional rehabilitation therapy take Buyanghuanwu Decoction,7d for a treatment course, for taking four courses, each treatment interval of 2d, respectively in the preoperative and postoperative 7d and postoperative 36d, Patients’recovery of spinal cord function is assessed with spinal cord JOA score assessment and Modified Barthel Index Scale, and description postoperative 7d and postoperative 36d with TCM syndrome diagnostic efficacy standards. The sets of data obtained using SPSS 18.0 for statistical analysis.Results:1. General data analysis:there had no statistical significance in sex, age, duration of disease and degree of spinal cord injury between the two groups (P>0.05).2. Spinal JOA score:the JOA score of spinal cord in the experimental group and control group was respectively (9.03±1.33), (9.17±1.11). Postoperative 7d, two groups’spinal JOA score was respectively (13.26±1.56), (12.37±1.58). Postoperative 36d, two groups’spinal JOA score was (15.05±1.58), (13.74±1.73). Preoperative JOA score of spinal cord differences between experimental group and control group had no statistical significance(P>0.05). Spinal cord JOA score’s difference before and after the surgery had significant differences both in the two groups(P<0.01). Postoperative 7d, compared with the control group, the experimental group JOA score increased more significantly, the difference has statistical significance(.P<0.05); postoperative 36d, compared with the control group, the experimental group JOA score increased more significantly, there was a significant difference(P<0.01).3. The activities of daily living:Preoperative experimental group and the control group’sBarthel index score was respectively (50.87±6.27), (53.80±5.60) points. Postoperative 7d, the two groups’ Barthel index score was respectively (77.70±7.40), (73.01±8.12). Postoperative 36d, the two groups’ Barthel index score was respectively (89.03±7.13), (81.70±8.11) points. Preoperative experimental group and control groups’ Barthel Index score difference for the activities of daily living has not statistical significance(P>0.05). The Barthel Index score’s differences for the activities of daily living between the preoperative and the postoperative had significant differences both in the two groups(P<0.01). Postoperative 7d, compared with the control group, the experimental group’s Barthel Index scores increased more significantly, the difference has statistical significance(P<0.05); postoperative 36d, compared with the control group, the experimental group’s Barthel Index scores increased more significantly, there was a significant difference(P<0.01).4. TCM syndrome diagnostic efficacy standards:Experimental group compared with control group in the TCM syndrome diagnostic efficacy standards. Postoperative 7d, the total effective rate was 83.3% in the experimental group, the total efficiency rate was 76.7% in the control group,the difference has statistical significance(P<0.05); postoperative 36d, the total effective rate of the experimental group was 93.3%, the total effective rate of the control group 86.7%; the total efficiency was higher in the experimental group, there was a significant difference(.P<0.01).Conclusions:Buyanghuanwu Decoction can promote functional recovery of spinal cord following CSM, with a good clinical effect.