| ObjectiveTo investigate the effect of Compound Danshen Driping pill on early diabetic lower extremity atherosclerotic disease (LEAD) by clinical research, and to explore its mechanism. This study is to provide certain theoretical basis for Compound Danshen Dripiing pill treatment of LEAD.70 patients with diabetic LEAD were randomly divided into two groups including the treatment group and the control group. Both groups were given routine treatments, such as controlling blood glucose, blood lipid and blood pressure, et al. The control group was treated with aspirin 100mg, once a day. Besides the routine treatment, the treatment group was treated with Compound Danshen Driping pill,15 grains one time, three times a day. Six months later, we observed the changes of clinical symptoms, glycosylated hemoglobin(HbAlc), Interleukin-6(IL-6), Tumor Necrosis Factor-a (TNF-a), Platelet CD62p, ankle brachial index and the blood vessel diameter between the treatment group and the control group.Results1. Patients in the two groups, there were no significant difference at the aspects of factors (P>0.05), such as gender, age, coures of disease, underling disease, blood glucose, blood-fat and body mass index. So the various factors of both groups could be consistent and comparable.2. After treatment, HbAlc, TNF-a, IL-6, CD62p vaules were decreased in two groups. The treatment group compared with the control group, HbAlc(6.38+0.67 vs 6.56±0.45, P>0.05), TNF-a (10.14±9.57 vs 12.42±15.21, P>0.05). There were significant difference in IL-6(21.89±21.44 vs 34.01±30.86, P< 0.05),CD62p(4.86±0.66 vs 5.22±0.70, P<0.05) between the treatment group and the control group. Compound Danshen Driping pill ameliorated the IL-6、 CD62p obviously (p<0.05)3. There were significant difference in ABI(0.81±0.28 vs 0.68±0.19, P <0.05), the blood vessel diameter of posterior tibial artery (2.25±0.33 vs 2.08±0.33, P<0.05) and dorsalis pedis artery (1.99±0.31 vs 1.81±.30, P <0.05) between the treatment group and the control group. Compound Danshen Driping pill ameliorated the ABI, the blood vessel diameter of posterior tibial artery and dorsalis pedis artery obviously (p<0.05).4. After treatment, the total syndrome scores in the treatment group was lower than the control group. There was statistically significant difference between the two groups. (P<0.05). In the treatment group,17 casts were remarkably improved,14 cases were effective,4 cases were ineffective and the effective rate was 88.57%(31/35). In the control group,5 casts were remarkably improved,20 cases were effective,10 cases were ineffective and the effective rate was 71.4%(25/35). The Compound Danshen Driping pill ameliorated the clinical therapeutic obviously (P<0.05).5. No obvious adverse reactions were found during the period of clincal treatment.ConclusionCompound danshen dropping pill was used to treat the Diabetic Lower Extremity Atherosclerotic Disease, which could improve the clinical symptoms. It could reduce the expression level of IL-6 and CD62p, improve the ABI and increase the blood vessel diameter of posterior tibial artery and dorsalis pedis artery. Its mechanism is to improve the blood supply of lower extremity by inhibiting platelet activation, anti-inflammatory reaction and dilating vessels. Compound Danshen Driping pill could relieve the progress of the Lower extremity atherosclerosis disease. |
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