The Study Of The Relationship Between OSAHS And Cerebral Infarction Associated With Atherosclerotic Multiple Vascular Beds Damage,and Correlation With ApoE4

Objective:The study of the relationship between OSAHS and cerebral infarction associated with atherosclerotic multiple vascular beds damage, and discuss correlation with apoE4 in OSAHS and cerebral infarction associated with atherosclerotic multiple vascular beds damage.Methods:We were collected suspected objects through department of neurology, the Second Affiliated Hospital of Kunming Medical University from May 2014 to July 2015.All subjects were suspected of the basic information check in the first day include:patient name, sex, age, number of hospital beds and other relevant information, and recorded in the register, and then edit the order of all patient records and the serial number in the register. All patients need detection of serum levels of lipids (total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein), polysomnography (PSG), cranial magnetic resonance imaging (MRI), head and neck artery angiography (CTA), neck vascular ultrasound, coronary angiography (CTA), double lower limbs artery ultrasonography during stay in this department. According to the above information to exclude non eligible patients, establish the cerebral infarction with non OSAHS (control group 25) and cerebral infarction with OSAHS (case group 36) patients as the final research object. To compare the difference of the total number of intracranial artery, carotid artery, coronary artery and lower extremity artery in patients with cerebral infarction with non OSAHS and cerebral infarction with OSAHS. According to the above information to confirmed that OSAHS has a certain role in promoted to cerebral infarction associated with atherosclerotic multiple vascular beds damage and distribution of atherosclerotic multiple vascular beds damage. The collected 61 patients according to the criteria and new stroke, screen out of cerebral infarction with non OSAHS (control group 20) and cerebral infarction with OSAHS (case group 20) patients as the final research object. The differences of serum apoE4 concentration between cerebral infarction with non OSAHS and cerebral infarction with OSAHS group were detected by enzyme linked immunosorbent assay. According to the above information to confirmed the correlation with apoE4 in OSAHS and cerebral infarction associated with atherosclerotic multiple vascular beds damage.Result:The levels of total cholesterol and triglyceride in cerebral infarction with non OSAHS group were significantly lower than that of cerebral infarction with OSAHS group (P<0.05). In further analysis of changes in lipid levels, we were found that three arteries injuries with the highest triglyceride levels. The total number of four arteries injuries in cerebral infarction with non OSAHS group accounted for 31%(31/100) was significantly lower than cerebral infarction with OSAHS group accounted for 74.31%(107/144). The differences between the two groups showed that OSAHS has a certain promotion effect on the atherosclerotic multiple vascular beds damage (P<0.05). The intracranial artery, carotid artery, coronary artery, lower extremity arterial injuries accounted for 75%(27/36),91.67%(33/36),50.00%(18/36), 80.56%(29/36) in cerebral infarction with OSAHS group. The carotid artery are more prone to atherosclerosis in cerebral infarction with OSAHS group (P<0.05). The OSAHS severity (mild, moderate and severe) had no effect on the total number of four arterial vascular injury and damage distribution (P>0.05). The correlation between apoE4 and blood lipid level has a statistical significance (P<0.05). The apoE4 in cerebral infarction with OSAHS associated with atherosclerotic multiple vascular beds damage has a certain correlation (P<0.05). The change of serum apoE4 concentration was more significant in patients with mild OSAHS (P<0.05). The effect of apoE on the distribution of atherosclerotic multiple vascular beds damage was not significant (P>0.05).Conclusion:OSAHS has a certain role in promoted to cerebral infarction associated with atherosclerotic multiple vascular beds damage and distribution of atherosclerotic multiple vascular beds damage. The apoE4 has a certain role in promoted to OSAHS and cerebral infarction associated with atherosclerotic multiple vascular beds damage.