| Purpose:The clinical characteristics of qi-yin deficiency syndrome in chronic glomerulonephritis has been studied to provide references and basis to discriminate this syndrome in clinical treatments of traditional Chinese medicine.Method:Patients who were hospitalized in Jiangsu Provincial Hospital of Traditional Chinese Medicine from March 1 to November 31,2015 were enrolled.A retrospective st udy was performed. Using microsoft excel software, the integral of qi-yin deficiency syn drome were calculated, and we collected and analyzed the clinical characteristics of the i ntegral, the general information (the age, the integral, the course of diseases and the path ological types), blood indexes (blood urea nitrogen, serum creatinine, uric acid, albumin, total cholesterol, triglyceride, kalium, calcium, phosphorus, carbon dioxide combining pow er) and urine indexes (urine protein, urine blood, urine leukocyte, urine erythrocyte, urine total protein), and made statistics processing to these data. According to the results of statistics, summaries of clinical characteristics of qi-yin deficiency syndromes in chronic nephritis had been made to provide references and basis to clinical prevention, diagnosis and treatment of the disease.Result:The characteristics of age distribution:the age was from 18 to 83. The average age of the patients was 49.25±15.02 years old, the average age of female patients was elder than the male. The distribution of population:youth group>middle-aged group> elderly group. The effect on the syndrome integral of different age groups was not obvious (P>0.05).Gender analysis:the ratio of male to female patients was 1:1.84. In each age group, the number of women was more than men. Male patient population distribution:youth group>elderly group>middle-aged group, female patient population distribution:middle-aged group>youth group> elderly group. There was no significant difference in the distribution of different genders of patients in each age group (P>0.05). And the influence of gender on syndrome integral was not obvious (P>0.05).The course analysis:the course was different from 3 months to 480 months. The number of the patients:the course of more than 24 months>the course of less than 12 months> the course in 13-24 months. The average duration of the patients was 58.73±92.53 months. The average duration of female patients was longer than that of male patients. Women were more than men in all disease course groups. The male patient was the most in the course of less than 12 months. Female patients in the course of more than 24 months was the most. The differences of the distribution between different gender patients on the course group was not significant(P>0.05). Qi and yin deficiency syndrome score:in the course of 13-24 months> duration less than 12 months> Course of more than 24 months. It could be considered to have a significant impact on qi and yin deficiency syndrome score in different courses (P<0.05).The characteristics of the renal pathological types:the ratio of people with renal biopsy and those nonresected was 1:2.71. The distribution of population:IgAN> MN> MsPGN(not IgAN)> MPGN, FSGS> MCD. The population of men and women was the largest in IgAN, followed by MN. Deficiency of both qi and yin syndrome integral mean value:MN> FSGS> IgAN, MsPGN(not IgAN)> MPGN> MCD. It could be considered that the effect of the pathological types of patients on qi and yin deficiency syndrome score was significant (P<0.01).Characteristics of blood index:the ALB and Ca2+, TC was significantly related to syndrome integral of deficiency of both qi and Yin(P<0.05). The syndrome integral mean value of the three indexes in abnormal people was higher than that in normal people, whether ALB and Ca2+was abnormal affected the syndrome score significantly (P<0.01). The differences among BUN, Scr, UA, TG, K+, P3+, CO2CP and the syndrome score were not statistically significant(P>0.05). In all blood parameters, ALB and deficiency of both qi and yin syndrome integral correlated most closely, followed by Ca2+, Scr and deficiency of both qi and yin syndrome integral correlation least closely.Urine index characteristics:(1) the population study:urine protein negative> urine protein +> urine protein++> urine protein+-> urine protein+++; occult blood negative> urine occult blood+++> urine occult blood+> urine occult blood++> urine occult blood+-> urine occult blood++++. The deficiency of both qi and yin syndrome integral mean value distribution:urine protein+++> urine protein++> urine protein+> urinary protein+-> urine protein negative; urine occult blood+++> urine occult blood negative> urine occult blood++ ++> urine occult blood+> urine occult blood+-> urine occult blood++. Different grades of urine protein significantly influenced the integral(P<0.01). The level of urine occult blood had no significant effect on the syndrome integral(P>0.05). UTP and syndromes integral significantly correlated (P< 0.01); Comparison of urine white blood cells, urine red blood cells and syndrome integral showed no significant meaning (P> 0.05). The correlation between UTP and syndrome score was the closest, followed by white blood cells, and the correlation between red blood cell and syndrome score was the least close.Conclusions:(1)The course of qi and yin deficiency syndrome in CGN is large. (2) Qi and yin deficiency of MN is the most severity, that of MCD is lightest.(3)Among the blood indexes,there is significant positive correlation in ALB and Ca2+ and qi-yin deficiency syndrome score, and the correlation in TC and qi-yin deficiency syndrome score is negative.(4)Among the urine indexes,there is positive correlation in urine protein and qi-yin deficiency syndrome score.The higher the level of urine protein is, the more serious degree of qi and Yin Syndrome will be. UTP and integral of qi and yin deficiency syndrome are positively related.(5)There is no correlation among age, sexes, BUN, Scr, UA, TG, K+, P3+, CO2CP, urine occult blood, urine white blood cells, urine red blood cells and qi-yin deficiency syndrome. So there is no correlation among qi-yin deficiency syndrome and factors like ages,sexes,progression of renal function and so on. |
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